Activating Compound | Comment | Organism | Structure |
---|---|---|---|
forskolin | decreased forskolin-stimulated adenylyl cyclase activity in suicide subjects | Homo sapiens | |
stimulating G protein | activating Gsalpha migrates from lipid rafts to nonraft membrane domains in prefrontal cortex and cerebellum in response to chronic, but not acute, treatment with tricyclic or selective serotonin reuptake inhibitor antidepressants, resulting in a more facile association with adenylyl cyclase and increased of cAMP formation. The alteration in membrane localization is unique to Gsalpha, another caveolae and lipid raft resident G-protein, Gqalpha is unaltered | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | - |
Homo sapiens | 16020 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP | Homo sapiens | brains from suicide subjects show abnormalities in the cAMP signaling cascade compared to healthy subjects | 3',5'-cyclic-AMP + diphosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | post-mortem Brodmanns area 9 and cerebellum from the right hemisphere from normal controls and suicide subjects, demographic characteristics, overview | Homo sapiens | - |
brain cortex | - |
Homo sapiens | - |
cerebellum | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP | - |
Homo sapiens | 3',5'-cyclic-AMP + diphosphate | - |
? | |
ATP | brains from suicide subjects show abnormalities in the cAMP signaling cascade compared to healthy subjects | Homo sapiens | 3',5'-cyclic-AMP + diphosphate | - |
? |