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Literature summary for 4.6.1.1 extracted from

  • Shan, Q.; Chan, G.C.; Storm, D.R.
    Type 1 adenylyl cyclase is essential for maintenance of remote contextual fear memory (2008), J. Neurosci., 28, 12864-12867.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 4.6.1.1

Application

Application Comment Organism
drug development AC1 is a potential drug target site to improve long-term remote memor Mus musculus

Protein Variants

Protein Variants Comment Organism
additional information mice overexpressing AC1 show superior remote contextual memory even though they exhibit normal hippocampus-dependent contextual memory, AC1 knockout mice show lower remote memory 11 weeks, but not within the first 5 weeks, after training compared with wild-type mice, phenotypes, overview Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP Mus musculus type 1 adenylyl cyclase is essential for maintenance of remote contextual fear memory 3',5'-cyclic-AMP + diphosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
 isozymne AC1
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Mus musculus
-
hippocampus
-
 Mus musculus
-
neuron
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP
-
 Mus musculus 3',5'-cyclic-AMP + diphosphate
-
 ?
ATP type 1 adenylyl cyclase is essential for maintenance of remote contextual fear memory Mus musculus 3',5'-cyclic-AMP + diphosphate
-
 ?

Synonyms

Synonyms Comment Organism
AC1
-
 Mus musculus
type 1 adenylyl cyclase
-
 Mus musculus