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Literature summary for 4.6.1.1 extracted from
- Essential roles of dopamine D4 receptors and the type 1 adenylyl cyclase in photic control of cyclic AMP in photoreceptor cells (2009), J. Neurochem., 109, 148-157.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| Calmodulin | activates | Mus musculus |  |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| gene Adcy1, DNA and amino acid sequence determination and analysis, expression analysis, genotyping | Mus musculus |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | Adcy1-/- mice lack the type 1 adenylyl cyclase, no compensatory changes in the levels of transcripts encoding the related type 8 adenylyl cyclase isoform in retinas of mice deficient in AC1, phenotype of AC1-deficient mice, overview. A dysfunction of Ca2+/CaM-stimulated adenylyl cyclase activity in Drd4-/-mouse retina appears to be due primarily to low levels of expression of the AC1 and not to changes in CaM expression | Mus musculus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| additional information | cyclic AMP levels in photoreceptor cells are highest in darkness and reduced by light exposure, dopamine D4 receptor activation promotes light adaptation and suppresses the light-sensitive pool of cyclic AMP in photoreceptor cells | Mus musculus |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Ca2+ | activates | Mus musculus | |
| Mg2+ | activates | Mus musculus | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP | Mus musculus | AC1 is a major adenylyl cyclase isoform controlling cyclic AMP synthesis in the mouse retina, dopamine receptor D4R activation tonically regulates the expression of AC1 in photoreceptors | 3',5'-cyclic-AMP + diphosphate | - |
? | |
| ATP | Mus musculus C57/BL6J | AC1 is a major adenylyl cyclase isoform controlling cyclic AMP synthesis in the mouse retina, dopamine receptor D4R activation tonically regulates the expression of AC1 in photoreceptors | 3',5'-cyclic-AMP + diphosphate | - |
? | |
| additional information | Mus musculus | the light- and dopamine D4 receptor-signaling pathways converge on the type 1 Ca2+/calmodulin-stimulated adenylyl cyclase to regulate cyclic AMP synthesis in photoreceptor cells, essential roles of D4 receptors and AC1 in photic control of cyclic AMP in photoreceptor cells, overview | ? | - |
? | |
| additional information | Mus musculus C57/BL6J | the light- and dopamine D4 receptor-signaling pathways converge on the type 1 Ca2+/calmodulin-stimulated adenylyl cyclase to regulate cyclic AMP synthesis in photoreceptor cells, essential roles of D4 receptors and AC1 in photic control of cyclic AMP in photoreceptor cells, overview | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
C57BL/6J mice | - |
| Mus musculus C57/BL6J | - |
C57BL/6J mice | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| photoreceptor cell | cyclic AMP levels in photoreceptor cells are highest in darkness and reduced by light exposure | Mus musculus | - |
| retina | AC1 is a major adenylyl cyclase isoform controlling cyclic AMP synthesis in the mouse retina | Mus musculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP | - |
Mus musculus | 3',5'-cyclic-AMP + diphosphate | - |
? | |
| ATP | AC1 is a major adenylyl cyclase isoform controlling cyclic AMP synthesis in the mouse retina, dopamine receptor D4R activation tonically regulates the expression of AC1 in photoreceptors | Mus musculus | 3',5'-cyclic-AMP + diphosphate | - |
? | |
| ATP | - |
Mus musculus C57/BL6J | 3',5'-cyclic-AMP + diphosphate | - |
? | |
| ATP | AC1 is a major adenylyl cyclase isoform controlling cyclic AMP synthesis in the mouse retina, dopamine receptor D4R activation tonically regulates the expression of AC1 in photoreceptors | Mus musculus C57/BL6J | 3',5'-cyclic-AMP + diphosphate | - |
? | |
| additional information | the light- and dopamine D4 receptor-signaling pathways converge on the type 1 Ca2+/calmodulin-stimulated adenylyl cyclase to regulate cyclic AMP synthesis in photoreceptor cells, essential roles of D4 receptors and AC1 in photic control of cyclic AMP in photoreceptor cells, overview | Mus musculus | ? | - |
? | |
| additional information | the light- and dopamine D4 receptor-signaling pathways converge on the type 1 Ca2+/calmodulin-stimulated adenylyl cyclase to regulate cyclic AMP synthesis in photoreceptor cells, essential roles of D4 receptors and AC1 in photic control of cyclic AMP in photoreceptor cells, overview | Mus musculus C57/BL6J | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| AC1 | - |
Mus musculus |
| type 1 adenylyl cyclase | - |
Mus musculus |
| type 1 Ca2+/calmodulin-stimulated adenylyl cyclase | - |
Mus musculus |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Mus musculus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.5 | - |
assay at | Mus musculus |
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