Cloned (Comment) | Organism |
---|---|
AC5, RT-PCR expression analysis | Mus musculus |
Protein Variants | Comment | Organism |
---|---|---|
additional information | mice lacking AC5 display strong reductions in anxiety-like behavior in several paradigms. This anxiolytic behavior in AC5-deficient mice is reduced by the D1 receptor antagonist SCH23390 and enhanced by the D1 dopamine receptor agonist, dihydrexidine or DHX. DHX-stimulated c-fos induction was enhanced in the dorso-medial striatum and NAc in AC5-deficient mice, phenotype, overview. siRNA-mediated inhibition of AC5 levels within the NAc is sufficient to produce an anxiolytic-like response, causing upregulation of prodynorphin and downregulation of cholecystokinin in the NAc of AC5-deficient mice, the effect is reversible by administration of nor-binaltorphimine, a kappa opioid receptor antagonist, or CCK-8s, a CCK receptor agonist, overview | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP | Mus musculus | - |
3',5'-cyclic-AMP + diphosphate | - |
? | |
additional information | Mus musculus | adenylyl cyclase-5 activity in the nucleus accumbens regulates anxiety-related behavior, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
isozyme AC5 | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | dorsal striatum and nucleus accumbens show a high content of isozyme AC5 | Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP | - |
Mus musculus | 3',5'-cyclic-AMP + diphosphate | - |
? | |
additional information | adenylyl cyclase-5 activity in the nucleus accumbens regulates anxiety-related behavior, overview | Mus musculus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
AC5 | - |
Mus musculus |
adenylyl cyclase-5 | - |
Mus musculus |