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Literature summary for 4.6.1.1 extracted from

  • Kim, K.S.; Lee, K.W.; Baek, I.S.; Lim, C.M.; Krishnan, V.; Lee, J.K.; Nestler, E.J.; Han, P.L.
    Adenylyl cyclase-5 activity in the nucleus accumbens regulates anxiety-related behavior (2008), J. Neurochem., 107, 105-115.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
AC5, RT-PCR expression analysis Mus musculus

Protein Variants

Protein Variants Comment Organism
additional information mice lacking AC5 display strong reductions in anxiety-like behavior in several paradigms. This anxiolytic behavior in AC5-deficient mice is reduced by the D1 receptor antagonist SCH23390 and enhanced by the D1 dopamine receptor agonist, dihydrexidine or DHX. DHX-stimulated c-fos induction was enhanced in the dorso-medial striatum and NAc in AC5-deficient mice, phenotype, overview. siRNA-mediated inhibition of AC5 levels within the NAc is sufficient to produce an anxiolytic-like response, causing upregulation of prodynorphin and downregulation of cholecystokinin in the NAc of AC5-deficient mice, the effect is reversible by administration of nor-binaltorphimine, a kappa opioid receptor antagonist, or CCK-8s, a CCK receptor agonist, overview Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP Mus musculus
-
3',5'-cyclic-AMP + diphosphate
-
?
additional information Mus musculus adenylyl cyclase-5 activity in the nucleus accumbens regulates anxiety-related behavior, overview ?
-
?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
isozyme AC5
-

Source Tissue

Source Tissue Comment Organism Textmining
brain dorsal striatum and nucleus accumbens show a high content of isozyme AC5 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP
-
Mus musculus 3',5'-cyclic-AMP + diphosphate
-
?
additional information adenylyl cyclase-5 activity in the nucleus accumbens regulates anxiety-related behavior, overview Mus musculus ?
-
?

Synonyms

Synonyms Comment Organism
AC5
-
Mus musculus
adenylyl cyclase-5
-
Mus musculus