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Literature summary for 4.6.1.1 extracted from

  • Kamanova, J.; Kofronova, O.; Masin, J.; Genth, H.; Vojtova, J.; Linhartova, I.; Benada, O.; Just, I.; Sebo, P.
    Adenylate cyclase toxin subverts phagocyte function by RhoA inhibition and unproductive ruffling (2008), J. Immunol., 181, 5587-5597.
    View publication on PubMed
Search for more literature for 4.6.1.1

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular CyaA is secreted Bordetella sp.
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP Bordetella sp. the secreted adenylate cyclase toxin is a key virulence factor of pathogenic Bordetellae, it penetrates murine host myeloid phagocytes expressing the alphaMbeta2, e.g. J774A.1 cells, RAW 264.7 cells, or bone marrow-derived macrophage-like cells, integrin and paralyzes their bactericidal capacities by uncontrolled conversion of ATP into a key signaling molecule cAMP. cAMP signaling of CyaA causes transient and selective inactivation of RhoA in mouse macrophages in the absence of detectable activation of Rac1, Rac2, or RhoG, modeling of CyaA-mediated subversion of phagocyte functions, overview 3',5'-cyclic-AMP + diphosphate
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 ?
additional information Bordetella sp. the CyaA/cAMP-induced drop of RhoA activity yielded dephosphorylation of the actinfilament severing protein cofilin and massive actin cytoskeleton rearrangements, which were paralleled by rapidly manifested macrophage ruffling and a rapid and unexpected loss of macropinocytic fluid phase uptake. CyaA/cAMP signaling further caused a rapid and near-complete block of complement-mediated phagocytosis. CyaA-induced membrane ruffling in host cells is transient and wanes faster at higher toxin concentration, overview ?
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 ?

Organism

Organism UniProt Comment Textmining
Bordetella sp.
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 gene cyaA
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP
-
 Bordetella sp. 3',5'-cyclic-AMP + diphosphate
-
 ?
ATP the secreted adenylate cyclase toxin is a key virulence factor of pathogenic Bordetellae, it penetrates murine host myeloid phagocytes expressing the alphaMbeta2, e.g. J774A.1 cells, RAW 264.7 cells, or bone marrow-derived macrophage-like cells, integrin and paralyzes their bactericidal capacities by uncontrolled conversion of ATP into a key signaling molecule cAMP. cAMP signaling of CyaA causes transient and selective inactivation of RhoA in mouse macrophages in the absence of detectable activation of Rac1, Rac2, or RhoG, modeling of CyaA-mediated subversion of phagocyte functions, overview Bordetella sp. 3',5'-cyclic-AMP + diphosphate
-
 ?
additional information the CyaA/cAMP-induced drop of RhoA activity yielded dephosphorylation of the actinfilament severing protein cofilin and massive actin cytoskeleton rearrangements, which were paralleled by rapidly manifested macrophage ruffling and a rapid and unexpected loss of macropinocytic fluid phase uptake. CyaA/cAMP signaling further caused a rapid and near-complete block of complement-mediated phagocytosis. CyaA-induced membrane ruffling in host cells is transient and wanes faster at higher toxin concentration, overview Bordetella sp. ?
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 ?

Synonyms

Synonyms Comment Organism
ACT
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 Bordetella sp.
adenylate cyclase toxin
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 Bordetella sp.
CyaA
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 Bordetella sp.