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Literature summary for 4.6.1.1 extracted from

  • Hallows, K.R.; Wang, H.; Edinger, R.S.; Butterworth, M.B.; Oyster, N.M.; Li, H.; Buck, J.; Levin, L.R.; Johnson, J.P.; Pastor-Soler, N.M.
    Regulation of epithelial Na+ transport by soluble adenylyl cyclase in kidney collecting duct cells (2009), J. Biol. Chem., 284, 5774-5783.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 4.6.1.1

Cloned(Commentary)

Cloned (Comment) Organism
expressed in mpkCCDc14 cells Rattus norvegicus

Protein Variants

Protein Variants Comment Organism
additional information RNA interference knockdown of soluble adenylyl cyclase in mpkCCDc14 cells leads to a yield of about 60% knockdown of the predominant somatic soluble adenylyl cyclase isoforms of 50-53 kDa, also amiloride-sensitive Isc is inhibited to a comparable extent Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
additional information soluble adenylyl cyclase inhibitors reduce not only basal Isc, but also Isc stimulated by two distinct agonists, forskolin and aldosterone, suggesting that soluble adenylyl cyclase activity may be regulating electrogenic Na+ transport at a site common to all pathways, soluble adenylyl cyclase inhibition blocks ATPase activity without affecting surface expression of the Na+ pump Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
soluble
-
 Rattus norvegicus
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP Rattus norvegicus regulation of epithelial Na+ transport by soluble adenylyl cyclase in kidney collecting duct cells, overview 3',5'-cyclic-AMP + diphosphate
-
 ?
additional information Rattus norvegicus soluble adenylyl cyclase inhibition blocks ATPase activity without affecting surface expression of the Na+ pump ?
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus Q9Z286 adult male Sprague-Dawley rats
-

Source Tissue

Source Tissue Comment Organism Textmining
epithelium epithelial cells, both intercalated cells and principal cells Rattus norvegicus
-
kidney
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP
-
 Rattus norvegicus 3',5'-cyclic-AMP + diphosphate
-
 ?
ATP regulation of epithelial Na+ transport by soluble adenylyl cyclase in kidney collecting duct cells, overview Rattus norvegicus 3',5'-cyclic-AMP + diphosphate
-
 ?
additional information soluble adenylyl cyclase inhibition blocks ATPase activity without affecting surface expression of the Na+ pump Rattus norvegicus ?
-
 ?

Synonyms

Synonyms Comment Organism
sAC
-
 Rattus norvegicus
soluble adenylyl cyclase
-
 Rattus norvegicus