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Literature summary for 4.6.1.1 extracted from

  • Okumura, S.; Tsunematsu, T.; Bai, Y.; Jiao, Q.; Ono, S.; Suzuki, S.; Kurotani, R.; Sato, M.; Minamisawa, S.; Umemura, S.; Ishikawa, Y.
    Type 5 adenylyl cyclase plays a major role in stabilizing heart rate in response to microgravity induced by parabolic flight (2008), J. Appl. Physiol., 105, 173-179.
    View publication on PubMedView publication on EuropePMC

Protein Variants

Protein Variants Comment Organism
additional information generation of transgenic mice with disrupted AC5 or overexpressing AC5, the latter type shows less decreased heart rate in later phases within one parabola, the inverse heart rate is more variable in AC5 knockout mice and less variable in AC5 overexpressing mice compared to wild-type mice, overview Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP Mus musculus the cardiac-specific isozyme AC5 plays an important role in regualting heart rate during parabolic flights, overview 3',5'-cyclic-AMP + diphosphate
-
?
ATP Mus musculus C57BL/6 the cardiac-specific isozyme AC5 plays an important role in regualting heart rate during parabolic flights, overview 3',5'-cyclic-AMP + diphosphate
-
?
additional information Mus musculus type 5 adenylyl cyclase plays a major role in stabilizing heart rate in response to microgravity induced by parabolic flight, overview ?
-
?
additional information Mus musculus C57BL/6 type 5 adenylyl cyclase plays a major role in stabilizing heart rate in response to microgravity induced by parabolic flight, overview ?
-
?

Organism

Organism UniProt Comment Textmining
Mus musculus P84309 C57BL/6 mice
-
Mus musculus C57BL/6 P84309 C57BL/6 mice
-

Source Tissue

Source Tissue Comment Organism Textmining
heart cardiac isozyme AC5 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP
-
Mus musculus 3',5'-cyclic-AMP + diphosphate
-
?
ATP the cardiac-specific isozyme AC5 plays an important role in regualting heart rate during parabolic flights, overview Mus musculus 3',5'-cyclic-AMP + diphosphate
-
?
ATP
-
Mus musculus C57BL/6 3',5'-cyclic-AMP + diphosphate
-
?
ATP the cardiac-specific isozyme AC5 plays an important role in regualting heart rate during parabolic flights, overview Mus musculus C57BL/6 3',5'-cyclic-AMP + diphosphate
-
?
additional information type 5 adenylyl cyclase plays a major role in stabilizing heart rate in response to microgravity induced by parabolic flight, overview Mus musculus ?
-
?
additional information type 5 adenylyl cyclase plays a major role in stabilizing heart rate in response to microgravity induced by parabolic flight, overview Mus musculus C57BL/6 ?
-
?

Synonyms

Synonyms Comment Organism
AC5
-
Mus musculus
type 5 adenylyl cyclase
-
Mus musculus