Activating Compound | Comment | Organism | Structure |
---|---|---|---|
A23187 | activates isozymes AC-I and AC-III | Mus musculus | |
forskolin | activates isozymes AC-I to AC-VIII, but not AC-IX, which contains no forskolin binding site | Mus musculus | |
additional information | superactivation method for the isozymes, overview | Mus musculus | |
SKF-82958 | a D1 dopaminergic receptor agonist | Mus musculus |
Cloned (Comment) | Organism |
---|---|
overexpression of nine membrane-bound isozymes in COS7 cells in absence of the D1 receptor | Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Li+ | lithium preferentially inhibits adenylyl cyclase V and VII isoforms, moderately also isozyme AC-II, but does not inhibit Ca2+-activated isozymes AC-I and AC-VIII, it interferes with the transduction pathways mediated via isozymes AC-V and AC-IIV. The inhibitor effect is abolished for the superactivated isozyme, overview | Mus musculus | |
quinpirole | inhibits the enzyme via Gi protein | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | nine membrane-bound isozymes | Mus musculus | 16020 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | stimulates the Ca2+-activated isozymes | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
isozymes AC-I-AC-IX | - |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Mus musculus |