Activating Compound | Comment | Organism | Structure |
---|---|---|---|
forskolin | - |
Homo sapiens | |
forskolin | - |
Rattus norvegicus | |
Sodium fluoride | - |
Homo sapiens | |
Sodium fluoride | - |
Rattus norvegicus | |
stimulating G protein | - |
Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
inhibitory G protein | - |
Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | - |
Homo sapiens | 16020 | - |
membrane | - |
Rattus norvegicus | 16020 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | activates | Homo sapiens | |
Mg2+ | activates | Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP | Homo sapiens | - |
3',5'-cyclic-AMP + diphosphate | - |
? | |
ATP | Rattus norvegicus | - |
3',5'-cyclic-AMP + diphosphate | - |
? | |
additional information | Rattus norvegicus | reduction of adenylyl cyclase activity induced by NaF and the increase in the Gi/Gs ratio can explain the changes in neurotransmission in olfactory bulbectomy rats, overview. Two weeks after surgery and compared to sham controls, olfactory bulbectomy rats display reduced NaF-stimulated adenylyl cyclase activity and increased Gi/Gs ratios in the hypothalamus, pre-frontal and cingulate cortices but not in the amygdala, hippocampus and caudate nucleus. No differences are found in basal or forskolin-stimulated conditions | ? | - |
? | |
additional information | Homo sapiens | reduction of adenylyl cyclase activity induced by NaF and the increase in the Gi/Gs ratio could explain the changes in neurotransmission in humans with depression | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Rattus norvegicus | - |
male Spague-Dawley rats | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | limbic system, induced and uninduced enzyme activity in different structures, overview | Homo sapiens | - |
brain | limbic system, induced and uninduced enzyme activity in different structures, overview | Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP | - |
Homo sapiens | 3',5'-cyclic-AMP + diphosphate | - |
? | |
ATP | - |
Rattus norvegicus | 3',5'-cyclic-AMP + diphosphate | - |
? | |
additional information | reduction of adenylyl cyclase activity induced by NaF and the increase in the Gi/Gs ratio can explain the changes in neurotransmission in olfactory bulbectomy rats, overview. Two weeks after surgery and compared to sham controls, olfactory bulbectomy rats display reduced NaF-stimulated adenylyl cyclase activity and increased Gi/Gs ratios in the hypothalamus, pre-frontal and cingulate cortices but not in the amygdala, hippocampus and caudate nucleus. No differences are found in basal or forskolin-stimulated conditions | Rattus norvegicus | ? | - |
? | |
additional information | reduction of adenylyl cyclase activity induced by NaF and the increase in the Gi/Gs ratio could explain the changes in neurotransmission in humans with depression | Homo sapiens | ? | - |
? |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
37 | - |
assay at | Rattus norvegicus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
assay at | Homo sapiens |
7.4 | - |
assay at | Rattus norvegicus |