Cloned (Comment) | Organism |
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polymorphism genotyping, and ADRB2 and ADCY6 gene interaction. The effect of ADRB2 on adhesion of erythrocytes in the sickle cell disease is different depending on the genotype of ADCY6. Sickle red cells from patients who were homozygous for either the G allele at single nucleotide polymorphism rs3730070 of ADCY6 demonstrate significantly increased adhesion to laminin compared to red cells from control patients, overview | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
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additional information | Homo sapiens | sickle red cell adhesion contributes to sickle cell disease pathophysiology, involving the gene interaction of gene ADCY6, encoding the adenylate cyclase, and gene ADRB2, encoding the beta2-adrenergic receptor, altered interaction affects sickel red cell adhesion to laminin, overview | ? | - |
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Organism | UniProt | Comment | Textmining |
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Homo sapiens | - |
gene ADCY6 | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | sickle red cell adhesion contributes to sickle cell disease pathophysiology, involving the gene interaction of gene ADCY6, encoding the adenylate cyclase, and gene ADRB2, encoding the beta2-adrenergic receptor, altered interaction affects sickel red cell adhesion to laminin, overview | Homo sapiens | ? | - |
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