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Literature summary for 4.6.1.1 extracted from

  • Lastro, M.; Collins, S.; Currie, W.B.
    Adenylyl cyclases in oocyte maturation: a characterization of AC isoforms in bovine cumulus cells (2006), Mol. Reprod. Dev., 73, 1202-1210.
    View publication on PubMed
Search for more literature for 4.6.1.1

Activating Compound

Activating Compound Comment Organism Structure
BIM-1 specific protein-kinase C inhibitor, significantly increases cumulus cell cAMP concentrations Bos taurus
clonidine slight stimulatory effect on cAMP concentrations Bos taurus
EGTA significantly increases cumulus cell cAMP concentrations Bos taurus
forskolin increases substantially cAMP concentrations Bos taurus
H89 specific inhibitor of protein-kinase A, significantly increases cumulus cell cAMP concentrations at 0.0001 and 0.03 mM Bos taurus
ionomycin increases intracellular Ca2+ concentrations, significantly increases cumulus cell cAMP concentrations Bos taurus
additional information cholera toxin, KN-62, phorbol-12-myristate-13-acetate and BAPTA-am or a combination of 3 mM EGTA plus BAPTA-am have no effect on cAMP concentrations Bos taurus
pertussis toxin catalyses ADP-ribosylation of a cysteine residue on GalphaI, causing the G-protein complex to become uncoupled from the receptor, significantly increases cAMP concentrations Bos taurus
staurosporine non-specific protein-kinase C inhibitor, significantly increases cumulus cell cAMP concentrations Bos taurus
thapsigargin increases intracellular Ca2+ concentrations, significantly increases cumulus cell cAMP concentrations Bos taurus

Application

Application Comment Organism
medicine cumulus cells possess multiple active isoforms of adenylyl cyclase, each isoform may have a specific role at a specific time during oocyte growth and maturation Bos taurus

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
 Bos taurus 16020
-

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain all nine membrane-associated isoforms Bos taurus
-
granulosa cell AC isoforms 3, 4, 6, 8, and 9 Bos taurus
-
additional information AC isoforms 1, 3, 4, 6, and 9 in cumulus cells. AC1, AC4 and AC6 predominate Bos taurus
-
ovary
-
 Bos taurus
-
testis sAC Bos taurus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP
-
 Bos taurus 3',5'-cAMP + diphosphate
-
 ?

Synonyms

Synonyms Comment Organism
AC1
-
 Bos taurus
AC2
-
 Bos taurus
AC3
-
 Bos taurus
AC4
-
 Bos taurus
AC5
-
 Bos taurus
AC6
-
 Bos taurus
AC7
-
 Bos taurus
AC8
-
 Bos taurus
AC9
-
 Bos taurus
adenylate cyclases I
-
 Bos taurus
adenylate cyclases IV
-
 Bos taurus
adenylate cyclases VI
-
 Bos taurus
sAC
-
 Bos taurus
soluble adenylyl cyclase
-
 Bos taurus