Activating Compound | Comment | Organism | Structure |
---|---|---|---|
Calmodulin | stimulates AC1 and AC8 in a Ca2+-dependent manner | Mus musculus | |
Calmodulin | stimulates AC8 in a Ca2+-dependent manner | Rattus norvegicus | |
forskolin | - |
Mus musculus |
Application | Comment | Organism |
---|---|---|
medicine | AC1 and AC8 involved in long-term memory and in N-methyl-D-aspartate-dependent long-term potentiation, AC1 and AC8 are not required for acute pain response. AC1 is the major Ca2+ sensor for N-methyl-D-aspartate receptor activation and excitotoxicity | Mus musculus |
Cloned (Comment) | Organism |
---|---|
- |
Mus musculus |
Protein Variants | Comment | Organism |
---|---|---|
additional information | mice deficient in AC1, are resistant to glutamate-induced neuronal toxicity, double knock-out AC1 and AC8 mice, show long lasting long-term potentiation and memory deficits that are greater in animals lacking both AC1 and AC8, when compared to animals deficient in only a single isoform. Behavioral responses to inflammatory stimuli that appear to involve N-methyl-D-aspartate receptor pathways are markedly reduced in double knockouts and AC1-/- mice. AC1-/- mice are resistant to glutamate-induced neuronal toxicity | Mus musculus |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | required by AC1 and AC8, AC1 is sensitive to lower concentrations of Ca2+ and shows a greater synergistic response to Ca2+ and Galphas than does AC8 | Mus musculus | |
Ca2+ | required by AC8 | Rattus norvegicus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
hippocampus | AC1 and AC8 highly expressed | Mus musculus | - |
hippocampus | AC8 highly expressed | Rattus norvegicus | - |
additional information | cortical neuron | Mus musculus | - |
neuron | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP | - |
Mus musculus | 3',5'-cAMP + diphosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
AC1 | - |
Mus musculus |
AC8 | - |
Mus musculus |
AC8 | - |
Rattus norvegicus |
adenylyl cyclase type 1 | - |
Mus musculus |
type VIII adenylyl cyclase | - |
Rattus norvegicus |