Literature summary for 4.6.1.1 extracted from

Wachten, S.; Schlenstedt, J.; Gauss, R.; Baumann, A.
Molecular identification and functional characterization of an adenylyl cyclase from the honeybee (2006), J. Neurochem., 96, 1580-1590.

Search for more literature for 4.6.1.1

Activating Compound

Activating Compound	Comment	Organism	Structure
Ca2+	-	Apis mellifera
forskolin	-	Apis mellifera
Gsalpha	signal transduction from beta-adrenergic receptors via trimeric Gs proteins to their downstream targets, e.g. ACs	Apis mellifera
additional information	neither ionomycin nor thapsigargin activate	Apis mellifera
norepinephrine	activates endogenously expressed b-adrenergic receptors, signal transduction from beta-adrenergic receptors via trimeric Gs proteins to their downstream targets, e.g. ACs	Apis mellifera

Application

Application	Comment	Organism
additional information	shares high sequence similarity (approximately 62%) with the Drosophila AC39E, enzyme serves in biogenic amine signal transduction cascades and in higher brain functions that contribute to learning and memory of the bee	Apis mellifera

Cloned(Commentary)

Cloned (Comment)	Organism
construction of a pcAmac3-HA expression vector, heterologous expression in flp-In-293 cells	Apis mellifera

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
membrane	-	Apis mellifera	16020	-

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Mg2+	-	Apis mellifera

Molecular Weight [Da]

Molecular Weight [Da]	Molecular Weight Maximum [Da]	Comment	Organism
101000	-	Western blot analysis	Apis mellifera
108000	-	Western blot analysis	Apis mellifera
110900	-	sequence analysis	Apis mellifera

Organism

Organism	UniProt	Comment	Textmining
Apis mellifera	Q1MU16	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
brain	highly expressed in somata of mushroom body neurones	Apis mellifera	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP	-	Apis mellifera	3',5'-cAMP + diphosphate	-	?

Synonyms

Synonyms	Comment	Organism
Amac3	-	Apis mellifera
group 1 adenylyl cyclase	-	Apis mellifera

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Release 2023.1 (January 2023)