Activating Compound | Comment | Organism | Structure |
---|---|---|---|
CO2 | induces acidification of cells, accompanied by a rise in intracellular HCO3- | Homo sapiens | |
HCO3- | mediates cAMP production | Homo sapiens |
Application | Comment | Organism |
---|---|---|
additional information | sAC is localized to motile airway cilia and it contributes to the regulation of human airway ciliary beat frequency in conditions of changing intracellular CO2/HCO3- via production of cAMP | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
ligated into pGEM-T Easy vector and expanded in DH5alpha Escherichia coli | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2-hydroxy-17beta-estradiol | specific sAC inhibitor, blocks CO2/HCO3- mediated cAMP production | Homo sapiens |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
50000 | - |
sAC form in axonemes, Western blot analysis | Homo sapiens |
75000 | - |
Western blot analysis | Homo sapiens |
190000 | - |
full-length form, Western blot analysis | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Purification (Comment) | Organism |
---|---|
by gel filtration | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
respiratory epithelium | specific localization of the 50 kDa isoform to the axoneme of ciliated airway epithelial cells | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP | - |
Homo sapiens | 3',5'-cAMP + diphosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
sAC | - |
Homo sapiens |
soluble adenylyl cyclase | - |
Homo sapiens |
pH Minimum | pH Maximum | Comment | Organism |
---|---|---|---|
additional information | - |
ciliary beat frequency is stimulated by cAMP independently of intracellular pH | Homo sapiens |