Literature summary for 4.6.1.1 extracted from

Baudouin-Legros, M.; Hamdaoui, N.; Borot, F.; Fritsch, J.; Ollero, M.; Planelles, G.; Edelman, A.
Control of Basal CFTR Gene Expression by Bicarbonate-Sensitive Adenylyl Cyclase in Human Pulmonary Cells (2008), Cell. Physiol. Biochem., 21, 75-86.

Search for more literature for 4.6.1.1

Activating Compound

Activating Compound	Comment	Organism	Structure
HCO3-	-	Homo sapiens

Application

Application	Comment	Organism
additional information	activation of the HCO3-/sAC transduction pathway enhances both cftr gene and CFTR protein expression and appears to be a physiological mechanism whereby the cell adapts to variations in extracellular HCO3- concentration	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
2OH-17beta estradiol	inhibits bicarbonate-induced cAMP production	Homo sapiens
additional information	not inhibited by 17beta-estradiol	Homo sapiens

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Ca2+	-	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
Calu-3 cell	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP	-	Homo sapiens	3',5'-cAMP + diphosphate	-	?

Synonyms

Synonyms	Comment	Organism
sAC	-	Homo sapiens
soluble adenylyl cyclase	-	Homo sapiens

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Release 2023.1 (January 2023)