Activating Compound | Comment | Organism | Structure |
---|---|---|---|
acetazolamide | when apical membrane insertion of the vacuolar proton pumping ATPase is stimulated by treatment with acetazolamide, sAC is also concentrated in the apical membrane of A-intercalated cells | Rattus norvegicus | |
bicarbonate | - |
Rattus norvegicus |
Application | Comment | Organism |
---|---|---|
medicine | sAC and the vacuolar proton pumping ATPase have a close association, may be part of a protein complex that is involved in regulating renal distal proton secretion | Mus musculus |
medicine | sAC and the vacuolar proton pumping ATPase have a close association, may be part of a protein complex that is involved in regulating renal distal proton secretion | Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytoplasm | apical domain of type A-intercalated cells | Rattus norvegicus | 5737 | - |
microvillus | apical domain of type A-intercalated cells | Rattus norvegicus | 5902 | - |
plasma membrane | sAC and the vacuolar proton pumping ATPase colocalize on or close to the apical plasma membrane in B1 vacuolar proton pumping ATPase deficient mice, colocalization does not require the B1 isoform | Mus musculus | 5886 | - |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
50000 | - |
immunoprecipitation, splice variant of the protein, which is the major functional sAC variant in many tissues | Rattus norvegicus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
adult male C57BL6 mice and B1 vacuolar proton pumping ATPase deficient mice | - |
Rattus norvegicus | - |
male sprague-dawley rats | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
kidney | 50 kDa splice variant and mRNA coding for full-length sAC | Rattus norvegicus | - |
kidney | collecting duct, apical domain of type A-intercalated cells | Mus musculus | - |
renal epithelium | in all intercalated cells, sAC and vacuolar proton pumping ATPase show considerable overlap under basal conditions, but sAC is also found in other cellular locations in the absence of vacuolar proton pumping ATPase. In type A-intercalated cells, both sAC and vacuolar proton pumping ATPase are apically and subapically located, whereas in type B-intercalated cells, significant basolateral colocalization of sAC and the vacuolar proton pumping ATPase is seen | Rattus norvegicus | - |
Synonyms | Comment | Organism |
---|---|---|
sAC | - |
Mus musculus |
sAC | - |
Rattus norvegicus |
soluble adenylyl cyclase | - |
Mus musculus |
soluble adenylyl cyclase | - |
Rattus norvegicus |