Activating Compound | Comment | Organism | Structure |
---|---|---|---|
ethanol | AC2 is less responsive to ethanol than rat AC3 or human AC7, N-terminal 28-amino-acid region of the C1a domain and the C-terminal region of the AC molecule are important for the enhancement of AC activity by ethanol | Rattus norvegicus | |
ethanol | AC3 is far less responsive, AC2 is less responsive to ethanol than human AC7, N-terminal 28-amino-acid region of the C1a domain and the C-terminal region of the adenylate cyclase molecule are important for the enhancement of adenylate cyclase activity by ethanol | Rattus norvegicus | |
ethanol | AC7 is the most ethanol responsive isoform, N-terminal 28-amino-acid region of the C1a domain and the C-terminal region of the AC molecule are important for the enhancement of AC activity by ethanol | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
chimeras inserted into the mammalian expression vector pCMV-SK, wild-type and chimeric mutants expressed in HEK-293 cells | Homo sapiens |
chimeras inserted into the mammalian expression vector pCMV-SK, wild-type and chimeric mutants expressed in HEK-293 cells | Rattus norvegicus |
Protein Variants | Comment | Organism |
---|---|---|
additional information | AC7-AC2 chimeric mutants, regardless of the origin of the N-terminal tail, C1b, M1, and M2 domains, the ethanol response of the mutant is similar to that of the parent isoform of AC, from which the C1a and C2 domains are derived | Rattus norvegicus |
additional information | AC7AC3 chimeric mutants, exchange of the putative transmembrane domains, M1 and M2 or of the N-terminal tail has no effect on the ethanol response of enzyme activity | Homo sapiens |
additional information | AC7AC3 chimeric mutants, exchange of the putative transmembrane domains, M1 and M2 or of the N-terminal tail has no effect on the ethanol response of enzyme activity | Rattus norvegicus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P51828 | - |
- |
Rattus norvegicus | P21932 | - |
- |
Rattus norvegicus | P26769 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP | - |
Homo sapiens | 3',5'-cAMP + diphosphate | - |
? | |
ATP | - |
Rattus norvegicus | 3',5'-cAMP + diphosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
AC2 | - |
Rattus norvegicus |
AC3 | - |
Rattus norvegicus |
AC7 | - |
Homo sapiens |