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Literature summary for 4.6.1.1 extracted from

  • Jaleel, M.; Shenoy, A.R.; Visweswariah, S.S.
    Tyrphostins Are Inhibitors of Guanylyl and Adenylyl Cyclases (2004), Biochemistry, 43, 8247-8255.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
tyrphostin A25 IC50 0.119mM, IC50 forskolin-stimulated adenylyl cyclase 1 mM, 37°C, pH 7.5 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
Homo sapiens 16020
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mn2+
-
Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HEK-293 cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP
-
Homo sapiens 3',5'-cAMP + diphosphate
-
?

Synonyms

Synonyms Comment Organism
adenylyl cyclase
-
Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.119
-
IC50 0.119mM, IC50 forskolin-stimulated adenylyl cyclase 1 mM, 37°C, pH 7.5 Homo sapiens tyrphostin A25