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Literature summary for 4.6.1.1 extracted from

  • Gille, A.; Guo, J.; Mou, T.C.; Doughty, M.B.; Lushington, G.H.; Seifert, R.
    Differential interactions of G-proteins and adenylyl cyclase with nucleoside 5'-triphosphates, nucleoside 5'-[g-thio]triphosphates and nucleoside 5'-[b,g-imido]triphosphates (2005), Biochem. Pharmacol., 71, 89-97.
    View publication on PubMed
Search for more literature for 4.6.1.1

Cloned(Commentary)

Cloned (Comment) Organism
expression in Sf9 cells Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
CTP
-
 Mus musculus
cytidine 5'-(gamma-thio)triphosphate
-
 Mus musculus
GTP
-
 Mus musculus
guanosine 5'-(beta,gamma-imido)triphosphate
-
 Mus musculus
guanosine 5'-(gamma-thio)triphosphate
-
 Mus musculus
inosine 5'-(beta,gamma-imido)triphosphate
-
 Mus musculus
inosine 5'-(gamma-thio)triphosphate
-
 Mus musculus
ITP
-
 Mus musculus
additional information inhibition studies of the purified catalytic subunits in the presence of forskolin Mus musculus
uridine 5'-(beta,gamma-imido)triphosphate
-
 Mus musculus
uridine 5'-(gamma-thio)triphosphate
-
 Mus musculus
UTP
-
 Mus musculus
xanthosine 5'-(beta,gamma-imido)triphosphate
-
 Mus musculus
xanthosine 5'-(gamma-thio)triphosphate
-
 Mus musculus
XTP
-
 Mus musculus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.1
-
 ATP Sf9, Mn2+, pH 7.4, 37°C, 100 microM forskolin, 10 mM NaF, 10 microM AlCl3 Mus musculus
0.15
-
 ATP S49 cyc-, pH 7.4, 37°C, Mn2+, 100 microM forskolin Mus musculus

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
 Mus musculus
Mn2+
-
 Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
S49 cell S49 lymphoma cell Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP
-
 Mus musculus cAMP + diphosphate
-
 ?

Synonyms

Synonyms Comment Organism
adenylyl cyclase
-
 Mus musculus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.015
-
 uridine 5'-(gamma-thio)triphosphate S49 cyc-, Mn2+, 100 microM forskolin Mus musculus
0.02
-
 xanthosine 5'-(gamma-thio)triphosphate S49 cyc-, Mn2+, 100 microM forskolin Mus musculus
0.02
-
 inosine 5'-(gamma-thio)triphosphate Sf9, Mn2+, 100 microM forskolin, 10 mM NaF, 10 microM AlCl3 Mus musculus
0.021
-
 inosine 5'-(gamma-thio)triphosphate S49 cyc-, Mn2+, 100 microM forskolin Mus musculus
0.025
-
 xanthosine 5'-(gamma-thio)triphosphate Sf9, Mn2+, 100 microM forskolin, 10 mM NaF, 10 microM AlCl3 Mus musculus
0.033
-
 cytidine 5'-(gamma-thio)triphosphate Sf9, Mn2+, 100 microM forskolin, 10 mM NaF, 10 microM AlCl3 Mus musculus
0.051
-
 uridine 5'-(gamma-thio)triphosphate Sf9, Mn2+, 100 microM forskolin, 10 mM NaF, 10 microM AlCl3 Mus musculus
0.071
-
 cytidine 5'-(gamma-thio)triphosphate S49 cyc-, Mn2+, 100 microM forskolin Mus musculus
0.35
-
 inosine 5'-(beta,gamma-imido)triphosphate S49 cyc-, Mn2+, 100 microM forskolin Mus musculus
0.4
-
 guanosine 5'-(gamma-thio)triphosphate Sf9, Mn2+, 100 microM forskolin, 10 mM NaF, 10 microM AlCl3 Mus musculus
0.41
-
 guanosine 5'-(gamma-thio)triphosphate S49 cyc-, Mn2+, 100 microM forskolin Mus musculus
0.44
-
 GTP Sf9, Mn2+, 100 microM forskolin, 10 mM NaF, 10 microM AlCl3 Mus musculus
0.48
-
 inosine 5'-(beta,gamma-imido)triphosphate Sf9, Mn2+, 100 microM forskolin, 10 mM NaF, 10 microM AlCl3 Mus musculus
0.55
-
 XTP S49 cyc-, Mn2+, 100 microM forskolin Mus musculus
0.6
-
 ITP S49 cyc-, Mn2+, 100 microM forskolin Mus musculus
0.67
-
 GTP S49 cyc-, Mn2+, 100 microM forskolin Mus musculus
0.95
-
 XTP Sf9, Mn2+, 100 microM forskolin, 10 mM NaF, 10 microM AlCl3 Mus musculus
0.99
-
 ITP Sf9, Mn2+, 100 microM forskolin, 10 mM NaF, 10 microM AlCl3 Mus musculus
1
-
 CTP S49 cyc-, Mn2+, 100 microM forskolin Mus musculus
1.1
-
 UTP S49 cyc-, Mn2+, 100 microM forskolin Mus musculus
2.2
-
 UTP Sf9, Mn2+, 100 microM forskolin, 10 mM NaF, 10 microM AlCl3 Mus musculus
2.4
-
 guanosine 5'-(beta,gamma-imido)triphosphate Sf9, Mn2+, 100 microM forskolin, 10 mM NaF, 10 microM AlCl3 Mus musculus
2.5
-
 uridine 5'-(beta,gamma-imido)triphosphate S49 cyc-, Mn2+, 100 microM forskolin Mus musculus
2.8
-
 uridine 5'-(beta,gamma-imido)triphosphate Sf9, Mn2+, 100 microM forskolin, 10 mM NaF, 10 microM AlCl3 Mus musculus
2.9
-
 CTP Sf9, Mn2+, 100 microM forskolin, 10 mM NaF, 10 microM AlCl3 Mus musculus
3
-
 guanosine 5'-(beta,gamma-imido)triphosphate S49 cyc-, Mn2+, 100 microM forskolin Mus musculus
10
-
 xanthosine 5'-(beta,gamma-imido)triphosphate S49 cyc-, Mn2+, 100 microM forskolin Mus musculus
10
-
 xanthosine 5'-(beta,gamma-imido)triphosphate Sf9, Mn2+, 100 microM forskolin, 10 mM NaF, 10 microM AlCl3 Mus musculus