Literature summary for 4.4.1.1 extracted from

Nandi, S.; Mishra, P.
H2S and homocysteine control a novel feedback regulation of cystathionine beta synthase and cystathionine gamma lyase in cardiomyocytes (2017), Sci. Rep., 7, 3639 .

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Organism

Organism	UniProt	Comment	Textmining
Mus musculus	Q8VCN5	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
cardiomyocyte cell line	-	Mus musculus	-

Expression

Organism	Comment	Expression
Mus musculus	presence of homocysteine upregulates cystathionine gamma lyase but downregulates cystathionine beta synthase whereas H2S-donor Na2S/GYY4137 downregulates cystathionine gamma lyase but upregulates cystathionine beta. The Na2S-treatment downregulates specificity protein-1, an inducer for cystathionine gamma lyase, and upregulates microRNA miR-133a that targets specificity protein-1, and inhibits cardiomyocytes hypertrophy. In the homocysteine-treated cardiomyocytes, cystathionine beta synthase and miR-133a are downregulated and hypertrophy is induced	additional information

General Information

General Information	Comment	Organism
physiological function	deficiency of cystathionine beta synthase upregulates cardiac cystathionine gamma lyase, plausibly by inducing specificity protein SP1	Mus musculus

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Release 2023.1 (January 2023)