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Literature summary for 4.3.3.2 extracted from

  • Chen, R.; Liao, Z.H.; Chen, M.; Wang, Q.; Yang, C.X.; Yang, Y.J.
    Molecular cloning and characterization of the strictosidine synthase gene from Rauwolfia verticillata (2008), Russ. J. Plant Physiol., 55, 670-675.
No PubMed abstract available
Search for more literature for 4.3.3.2

Cloned(Commentary)

Cloned (Comment) Organism
gene RvSTR, DNA and amino acid sequence determination and analysis, sequence comparison and phylogenetic analysis Rauvolfia verticillata

Protein Variants

Protein Variants Comment Organism
biotechnology the enzyme encoding gene is a candidate gene for metabolic engineering of the TIA pathway in Rauwolfia verticillata Rauvolfia verticillata

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
38200
-
 x * 38200, about, sequence calculation Rauvolfia verticillata

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
tryptamine + secologanin Rauvolfia verticillata the strictosidine synthase catalyzes the condensation of tryptamine and secologanin to form strictosidine, which is the universal precursor for a wide range of pharmaceutical terpenoid indole alkaloids, TIA, e.g. in biosynthesis of reserpine and ajmalicine from the Chinese native TIAs-producing plant, overview 3-alpha(S)-strictosidine + H2O
-
 ?

Organism

Organism UniProt Comment Textmining
Rauvolfia verticillata Q1L6F4
-
-

Source Tissue

Source Tissue Comment Organism Textmining
flower
-
 Rauvolfia verticillata
-
fruit
-
 Rauvolfia verticillata
-
leaf
-
 Rauvolfia verticillata
-
additional information tissue expression pattern analysis, overview Rauvolfia verticillata
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root
-
 Rauvolfia verticillata
-
stem
-
 Rauvolfia verticillata
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
tryptamine + secologanin the strictosidine synthase catalyzes the condensation of tryptamine and secologanin to form strictosidine, which is the universal precursor for a wide range of pharmaceutical terpenoid indole alkaloids, TIA, e.g. in biosynthesis of reserpine and ajmalicine from the Chinese native TIAs-producing plant, overview Rauvolfia verticillata 3-alpha(S)-strictosidine + H2O
-
 ?
tryptamine + secologanin the unique essential and conserved catalytic residue is Glu309 Rauvolfia verticillata 3-alpha(S)-strictosidine + H2O
-
 ?

Subunits

Subunits Comment Organism
? x * 38200, about, sequence calculation Rauvolfia verticillata

Synonyms

Synonyms Comment Organism
str
-
 Rauvolfia verticillata

pI Value

Organism Comment pI Value Maximum pI Value
Rauvolfia verticillata sequence calculation
-
 5.19