Literature summary for 4.3.3.2 extracted from

Ma, X.; Koepke, J.; Fritzsch, G.; Diem, R.; Kutchan, T.M.; Michel, H.; Stockigt, J.
Crystallization and preliminary X-ray crystallographic analysis of strictosidine synthase from Rauvolfia: the first member of a novel enzyme family (2004), Biochim. Biophys. Acta, 1702, 121-124.

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Application

Application	Comment	Organism
medicine	anti-cancer, anti-hypertensive, anti-malaria and anti-arrhythmic ajmaline agents	Rauvolfia serpentina
synthesis	involved in the biosynthesis of almost all plant monoterpenoid indole alkaloids	Rauvolfia serpentina

Cloned(Commentary)

Cloned (Comment)	Organism
cloned with His-tag, expression in Escherichia coli strain M15, after expression and Ni-NTA column removed by DAPase	Rauvolfia serpentina

Crystallization (Commentary)

Crystallization (Comment)	Organism
2.95 A under cryoconditions, crystal growing by hanging drop vapor diffusion, 303 K, 0.8 M potassium sodium tartrate tetrahydrate,pH 7.5 - 8.0	Rauvolfia serpentina

Molecular Weight [Da]

Molecular Weight [Da]	Molecular Weight Maximum [Da]	Comment	Organism
35300	-	calculated, SDS-PAGE	Rauvolfia serpentina

Organism

Organism	UniProt	Comment	Textmining
Rauvolfia serpentina	-	-	-

Purification (Commentary)

Purification (Comment)	Organism
-	Rauvolfia serpentina

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
tryptamine + secologanin	-	Rauvolfia serpentina	3alpha(S)-strictosidine	-	?

Synonyms

Synonyms	Comment	Organism
STR1	-	Rauvolfia serpentina

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Release 2023.1 (January 2023)