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Literature summary for 4.3.2.1 extracted from
- Intragenic complementation and the structure and function of argininosuccinate lyase (2000), Cell. Mol. Life Sci., 57, 1637-1651.
General Stability
| General Stability | Organism |
|---|---|
| ASL undergoes cold dissociation via a dimer intermediate | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| citrulline | noncompetitive vs. fumarate and arginine | Homo sapiens |  |
| succinate | noncompetitive vs. fumarate and arginine | Homo sapiens | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.2 | - |
argininosuccinate | - |
Homo sapiens | |
| 3 | - |
arginine | - |
Homo sapiens | |
| 5.3 | - |
fumarate | - |
Homo sapiens | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytosol | - |
Homo sapiens | 5829 | - |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 51600 | - |
4 * 51600, deduced from nucleotide sequence | Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| (Nomega-L-arginino)succinate | Homo sapiens | - |
fumarate + L-arginine | - |
r | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
mutations in ASL result the clinical condition argininosuccinate aciuria | - |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| liver ASL | Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | - |
Homo sapiens | - |
| erythrocyte | - |
Homo sapiens | - |
| heart | - |
Homo sapiens | - |
| kidney | - |
Homo sapiens | - |
| liver | predominant expression | Homo sapiens | - |
| muscle | - |
Homo sapiens | - |
| pancreas | - |
Homo sapiens | - |
| skin fibroblast | - |
Homo sapiens | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 8 | - |
synthesis of argininosuccinate | Homo sapiens |
| 10.3 | - |
deamination of argininosuccinate | Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| (Nomega-L-arginino)succinate | - |
Homo sapiens | fumarate + L-arginine | - |
? | |
| (Nomega-L-arginino)succinate | - |
Homo sapiens | fumarate + L-arginine | - |
r | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| tetramer | 4 * 51600, deduced from nucleotide sequence | Homo sapiens |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| ASL | - |
Homo sapiens |
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Release 2023.1 (January 2023)
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