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Literature summary for 4.3.1.19 extracted from

  • Kim, S.S.; Datta, P.
    Chemical characterization of biodegradative threonine dehydratases from two enteric bacteria (1982), Biochim. Biophys. Acta, 706, 27-35.
    View publication on PubMed
Search for more literature for 4.3.1.19

Inhibitors

Inhibitors Comment Organism Structure
pyruvate uncompetitive inhibition and substrate inhibition with respect to L-Thr, noncompetitive inhibition with respect to AMP Escherichia coli
pyruvate noncompetitive inhibition with respect to L-Thr, mixed type inhibition with respect to AMP Salmonella enterica subsp. enterica serovar Typhimurium

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3
-
 L-Thr with AMP Salmonella enterica subsp. enterica serovar Typhimurium
8
-
 L-Thr with AMP Salmonella enterica subsp. enterica serovar Typhimurium
70
-
 L-Thr without AMP Escherichia coli
125
-
 L-Thr without AMP Salmonella enterica subsp. enterica serovar Typhimurium

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
36000
-
 x * 36000, SDS-PAGE Salmonella enterica subsp. enterica serovar Typhimurium
38000
-
 x * 38000, SDS-PAGE Escherichia coli

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-
Escherichia coli
-
 biodegradative threonine dehydratase
-
Escherichia coli
-
 ATCC 14948
-
Escherichia coli K 12
-
-
-
Salmonella enterica subsp. enterica serovar Typhimurium
-
-
-
Salmonella enterica subsp. enterica serovar Typhimurium
-
 biodegradative threonine dehydratase
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-threonine
-
 Salmonella enterica subsp. enterica serovar Typhimurium 2-oxobutanoate + NH3
-
 ?
L-threonine
-
 Escherichia coli 2-oxobutanoate + NH3
-
 ?
L-threonine
-
 Escherichia coli K 12 2-oxobutanoate + NH3
-
 ?

Subunits

Subunits Comment Organism
tetramer x * 38000, SDS-PAGE Escherichia coli
tetramer x * 36000, SDS-PAGE Salmonella enterica subsp. enterica serovar Typhimurium

Cofactor

Cofactor Comment Organism Structure
ADP stimulation Salmonella enterica subsp. enterica serovar Typhimurium
ADP no stimulation by ADP Escherichia coli
pyridoxal 5'-phosphate cofactor Salmonella enterica subsp. enterica serovar Typhimurium
pyridoxal 5'-phosphate cofactor Escherichia coli
pyridoxal 5'-phosphate contains 2 mol of pyridoxal 5'-phosphate per mol of enzyme Salmonella enterica subsp. enterica serovar Typhimurium
pyridoxal 5'-phosphate contains 2 mol of pyridoxal 5'-phosphate per mol of enzyme Escherichia coli