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Literature summary for 4.3.1.19 extracted from
- Purification and some properties of L-threonine dehydratase from Candida maltosa (1986), J. Basic Microbiol., 26, 443-451.
No PubMed abstract available
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| L-Val | activates | Candida maltosa |  |
| phosphate | increases activity | Candida maltosa | |
| phosphate | maximal stimulation at 200 mM | Candida maltosa | |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Hg2+ | - |
Candida maltosa | |
| Ile | 50% inhibition at 0.14 mM Ile, 98% inhibition at 1 mM Ile | Candida maltosa | |
| PCMB | - |
Candida maltosa | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 3 | - |
L-Thr | - |
Candida maltosa | |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| additional information | no requirement for divalent cations | Candida maltosa |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 46000 | - |
4 * 46000, SDS-PAGE | Candida maltosa |
| 190000 | - |
gel filtration | Candida maltosa |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Candida maltosa | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Candida maltosa |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
- |
Candida maltosa |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-homoserine | - |
Candida maltosa | 2-oxobutanoate + NH3 + H2O | - |
? | |
| L-serine | - |
Candida maltosa | pyruvate + NH3 | - |
? | |
| L-threonine | - |
Candida maltosa | 2-oxobutanoate + NH3 | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| tetramer | 4 * 46000, SDS-PAGE | Candida maltosa |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 8.8 | - |
- |
Candida maltosa |
pH Range
| pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|
| 8.1 | 9.6 | 50% of maximal activity at pH 8.1 and 9.6 | Candida maltosa |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| pyridoxal 5'-phosphate | cofactor | Candida maltosa | |
| pyridoxal 5'-phosphate | Km: 0.00028 mM | Candida maltosa | |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.14 | - |
Ile | - |
Candida maltosa | |
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