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Literature summary for 4.2.99.21 extracted from
- Exploration of swapping enzymatic function between two proteins: a simulation study of chorismate mutase and isochorismate pyruvate lyase (2013), Protein Sci., 22, 809-822.
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| isochorismate | Pseudomonas aeruginosa | - |
salicylate + pyruvate | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Pseudomonas aeruginosa | - |
gene pchB | - |
Reaction
| Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|
| isochorismate = salicylate + pyruvate | reaction mechanism, the IPL reaction is a concerted but asynchronous hydrogen transfer, by a proposed [1,5]-sigmatropic reaction mechanism with a pericyclic transition state, quantum mechanical/molecular-mechanical calculations and simulations, overview | Pseudomonas aeruginosa |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| isochorismate | - |
Pseudomonas aeruginosa | salicylate + pyruvate | - |
? | |
| isochorismate | pericyclic reaction, elimination of pyruvate. The electrostatic field due to PchB at atoms of isochorismate favors the isochorismate to salicylate transition, molecular dynamics simulations, overview | Pseudomonas aeruginosa | salicylate + pyruvate | - |
? | |
| additional information | PchB possesses weak chorismate mutase activity as well and is able to catalyze two distinct pericyclic reactions in a single active site. The enzyme tends to bring its non-native substrate in the same conformation as its native substrate | Pseudomonas aeruginosa | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| IPL | - |
Pseudomonas aeruginosa |
| isochorismate pyruvate lyase | - |
Pseudomonas aeruginosa |
| PchB | - |
Pseudomonas aeruginosa |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | the enzyme physiologically catalyzes the elimination of the enolpyruvyl side chain from isochorismate to make salicylate for incorporation into the siderophore pyochelin | Pseudomonas aeruginosa |
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Release 2023.1 (January 2023)
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