Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Kainic acid | APE/Ref-1 is decreased by kainic acid injury in a time-dependent manner at the level of proteins, not transcripts | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
General Information | Comment | Organism |
---|---|---|
physiological function | overexpression of APE/Ref-1 using adenovirus and restoration of APE small peptides significantly reduces kainic acid-induced hippocampal cell death. Both silencing of APE/Ref-1 by siRNA and inhibition of endonuclease by an antibody significantly increase caspase-3 activity and apoptotic cell death triggered from the early time after exposure to kainic acid. Findings suggest that cell death is initiated by reducing APE/Ref-1 protein and inhibiting its repair function in spite of enough protein amounts | Mus musculus |