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Literature summary for 4.2.99.18 extracted from

  • Wu, H.H.; Cheng, Y.W.; Chang, J.T.; Wu, T.C.; Liu, W.S.; Chen, C.Y.; Lee, H.
    Subcellular localization of apurinic endonuclease 1 promotes lung tumor aggressiveness via NF-kappaB activation (2010), Oncogene, 29, 4330-4340.
    View publication on PubMed

Application

Application Comment Organism
medicine patients with tumors containing elevated cytoplasmic Ape1 have a poor prognosis and a 3.722fold risk of tumor recurrence and/or metastasis Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
7-nitro-1H-indole-2-carboxylic acid CRT0044876 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
Homo sapiens 5737
-
nucleus
-
Homo sapiens 5634
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
A-549 cell
-
Homo sapiens
-
Calu-1 cell
-
Homo sapiens
-
CH-27 cell
-
Homo sapiens
-
CL-3 cell
-
Homo sapiens
-
lung cancer cell
-
Homo sapiens
-
NCI-H157 cell
-
Homo sapiens
-
NCI-H1975 cell
-
Homo sapiens
-
NCI-H441 cell
-
Homo sapiens
-
NCI-H520 cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
DNA
-
Homo sapiens fragments of DNA
-
?

Synonyms

Synonyms Comment Organism
APE1
-
Homo sapiens
apurinic endonuclease 1
-
Homo sapiens

General Information

General Information Comment Organism
physiological function nuclear factor -kappaB is activated by cytoplasmic, but not nuclear, Ape1 to cause Cox-2 expression. Ape1 can enhance lung tumor malignancy through nuckear factor-kappaB activation Homo sapiens