Application | Comment | Organism |
---|---|---|
medicine | patients with tumors containing elevated cytoplasmic Ape1 have a poor prognosis and a 3.722fold risk of tumor recurrence and/or metastasis | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
7-nitro-1H-indole-2-carboxylic acid | CRT0044876 | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytoplasm | - |
Homo sapiens | 5737 | - |
nucleus | - |
Homo sapiens | 5634 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
A-549 cell | - |
Homo sapiens | - |
Calu-1 cell | - |
Homo sapiens | - |
CH-27 cell | - |
Homo sapiens | - |
CL-3 cell | - |
Homo sapiens | - |
lung cancer cell | - |
Homo sapiens | - |
NCI-H157 cell | - |
Homo sapiens | - |
NCI-H1975 cell | - |
Homo sapiens | - |
NCI-H441 cell | - |
Homo sapiens | - |
NCI-H520 cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
DNA | - |
Homo sapiens | fragments of DNA | - |
? |
Synonyms | Comment | Organism |
---|---|---|
APE1 | - |
Homo sapiens |
apurinic endonuclease 1 | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | nuclear factor -kappaB is activated by cytoplasmic, but not nuclear, Ape1 to cause Cox-2 expression. Ape1 can enhance lung tumor malignancy through nuckear factor-kappaB activation | Homo sapiens |