Cloned (Comment) | Organism |
---|---|
expressed in Escherichia coli Rosetta cells | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2,4,9-trimethylbenzo[b][1,8]naphthyridin-5-amine | i.e. Ape1 repair inhibitor 03, specific inhibitor of AP endonuclease | Homo sapiens | |
2-(4-(2,5-dimethyl-1H-prryol-1-yl)phenoxy) acetic acid | i.e. Ape1 repair inhibitor 01, specific inhibitor of AP endonuclease | Homo sapiens | |
4-(2,6,8-trimethylquinolin-4-ylamino)phenol | i.e. Ape1 repair inhibitor 02, specific inhibitor of AP endonuclease | Homo sapiens | |
A1NI2-A3NI1 | - |
Homo sapiens | |
N-(3-chlorophenyl)-5,6-dihyro-4H-cyclopenta[d]isoxazole-3-carboxamide | i.e. Ape1 repair inhibitor 06, specific inhibitor of AP endonuclease | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Purification (Comment) | Organism |
---|---|
Ni-NTA column chromatography, S-Sepharose column chromatography | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
glioblastoma cell | - |
Homo sapiens | - |
SF-767 cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
DNA | Ape1 cleaves the phosphodiester backbone 5' to the AP site generating 3'-hydroxyl and 5'-deoxyribosephosphate termini, Ape1 exhibits a prominent 5' hydrolytic AP endonuclease, a weak 3'-diesterase and a 3'-5'-exonuclease activity | Homo sapiens | fragments of DNA | - |
? |
Synonyms | Comment | Organism |
---|---|---|
AP endonuclease 1 | - |
Homo sapiens |
APE1 | - |
Homo sapiens |
apurinic/apyrimidinic endonuclease | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0016 | - |
- |
Homo sapiens | N-(3-chlorophenyl)-5,6-dihydro-4H-cyclopenta[d]isoxazole-3-carboxamide | |
0.0017 | - |
- |
Homo sapiens | [4-(2,5-dimethyl-1H-pyrrol-1-yl)phenoxy]acetic acid | |
0.0021 | - |
- |
Homo sapiens | 2,4,9-trimethylpyridino[2,3-b]quinoline-5-ylamine | |
0.0064 | - |
- |
Homo sapiens | 4-((2,6,8-trimethylquinolin-4-yl)amino)phenol |