Inhibitors | Comment | Organism | Structure |
---|---|---|---|
EDTA | complete inhibition at 1 mM | Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | required for APE1-catalyzed endonuclease activity | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
DNA | - |
Homo sapiens | fragments of DNA | - |
? |
Synonyms | Comment | Organism |
---|---|---|
AP endonuclease 1 | - |
Homo sapiens |
APE1 | - |
Homo sapiens |
apurinic endonuclease 1 | also known as Ref-1 or HAP1 | Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | APE1 stimulates the multiple-turnover excision of hypoxanthine by alkyladenine DNA glycosylase but has no effect on single-turnover excision | Homo sapiens |