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Literature summary for 4.2.99.18 extracted from

  • Baldwin, M.R.; OBrien, P.J.
    Human AP endonuclease 1 stimulates multiple-turnover base excision by alkyladenine DNA glycosylase (2009), Biochemistry, 48, 6022-6033.
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
EDTA complete inhibition at 1 mM Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required for APE1-catalyzed endonuclease activity Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
DNA
-
Homo sapiens fragments of DNA
-
?

Synonyms

Synonyms Comment Organism
AP endonuclease 1
-
Homo sapiens
APE1
-
Homo sapiens
apurinic endonuclease 1 also known as Ref-1 or HAP1 Homo sapiens

General Information

General Information Comment Organism
physiological function APE1 stimulates the multiple-turnover excision of hypoxanthine by alkyladenine DNA glycosylase but has no effect on single-turnover excision Homo sapiens