Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
nucleus | decrease on APE/Ref-1 levels and an increase in oxidative DNA damage scores in the nucleus of neurons after acute and chronic injury in the caudal section | Rattus norvegicus | 5634 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
DNA | Rattus norvegicus | DNA repair enzyme is involved in base excision repair of apurinic/apyrimidinic sites after oxidative DNA damage | fragments of DNA | - |
? | |
additional information | Rattus norvegicus | an increase of APE/Ref-1 mRNA levels in the caudal region of spinal cord strongly correlates with DNA damage after traumatic spinal cord injury | ? | - |
? | |
additional information | Rattus norvegicus | multifunctional protein involved in both the repair of oxidative and alkylating DNA damage and the regulation of gene expression | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
female Sprague-Dawley rats with spinal cord injury | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
embryonic neural stem cell | NRP and GRP-neuronal and glial restricted precursors are isolated from embryonic day 13.5 rats and transplantated into rats. | Rattus norvegicus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
mRNA levels of APE/Ref-1 decrease 43.36% and increase 31.75% in acute spinal cord injury and spinal cord injury plus embryonic neural stem cells therapy groups, respectively in acute study groups and decrease 31.97% and increase 65.13% in chronic spinal cord injury and spinal cord injury plus embryonic neural stem cells therapy groups in chronic study groups, when compared to the sham. After embryonic neural stem cells therapy, in both acute and chronic spinal cord injury groups APE/Ref-1 levels significantly improve. | Rattus norvegicus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
DNA | DNA repair enzyme is involved in base excision repair of apurinic/apyrimidinic sites after oxidative DNA damage | Rattus norvegicus | fragments of DNA | - |
? | |
additional information | an increase of APE/Ref-1 mRNA levels in the caudal region of spinal cord strongly correlates with DNA damage after traumatic spinal cord injury | Rattus norvegicus | ? | - |
? | |
additional information | multifunctional protein involved in both the repair of oxidative and alkylating DNA damage and the regulation of gene expression | Rattus norvegicus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Ape | - |
Rattus norvegicus |
APE/Ref-1 | - |
Rattus norvegicus |
apurinic/apyrimidinic endonuclease/redox effector factor-1 | - |
Rattus norvegicus |