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Literature summary for 4.2.99.18 extracted from

  • Dagci, T.; Armagan, G.; Konyalioglu, S.; Yalcin, A.
    Alterations in the expression of the apurinic/apyrimidinic endonuclease-1/redox factor-1 (APE/Ref-1) and DNA damage in the caudal region of acute and chronic spinal cord injured rats treated by embryonic neural stem cells (2008), Physiol. Res., 58, 427-434.
    View publication on PubMed

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus decrease on APE/Ref-1 levels and an increase in oxidative DNA damage scores in the nucleus of neurons after acute and chronic injury in the caudal section Rattus norvegicus 5634
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
DNA Rattus norvegicus DNA repair enzyme is involved in base excision repair of apurinic/apyrimidinic sites after oxidative DNA damage fragments of DNA
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?
additional information Rattus norvegicus an increase of APE/Ref-1 mRNA levels in the caudal region of spinal cord strongly correlates with DNA damage after traumatic spinal cord injury ?
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?
additional information Rattus norvegicus multifunctional protein involved in both the repair of oxidative and alkylating DNA damage and the regulation of gene expression ?
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?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
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female Sprague-Dawley rats with spinal cord injury
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Source Tissue

Source Tissue Comment Organism Textmining
embryonic neural stem cell NRP and GRP-neuronal and glial restricted precursors are isolated from embryonic day 13.5 rats and transplantated into rats. Rattus norvegicus
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Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
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mRNA levels of APE/Ref-1 decrease 43.36% and increase 31.75% in acute spinal cord injury and spinal cord injury plus embryonic neural stem cells therapy groups, respectively in acute study groups and decrease 31.97% and increase 65.13% in chronic spinal cord injury and spinal cord injury plus embryonic neural stem cells therapy groups in chronic study groups, when compared to the sham. After embryonic neural stem cells therapy, in both acute and chronic spinal cord injury groups APE/Ref-1 levels significantly improve. Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
DNA DNA repair enzyme is involved in base excision repair of apurinic/apyrimidinic sites after oxidative DNA damage Rattus norvegicus fragments of DNA
-
?
additional information an increase of APE/Ref-1 mRNA levels in the caudal region of spinal cord strongly correlates with DNA damage after traumatic spinal cord injury Rattus norvegicus ?
-
?
additional information multifunctional protein involved in both the repair of oxidative and alkylating DNA damage and the regulation of gene expression Rattus norvegicus ?
-
?

Synonyms

Synonyms Comment Organism
Ape
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Rattus norvegicus
APE/Ref-1
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Rattus norvegicus
apurinic/apyrimidinic endonuclease/redox effector factor-1
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Rattus norvegicus