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Literature summary for 4.2.99.18 extracted from

  • Merluzzi, S.; Gri, G.; Gattei, V.; Pagano, M.; Pucillo, C.
    APE/Ref-1 makes fine-tuning of CD40-induced B cell proliferation (2008), Mol. Immunol., 45, 3731-3739.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
repression of APE/Ref-1 by an antisense overexpression, transfection of mouse B-cells with phosphorothioate oligonucleotide, which is complementary to the APE/Ref-1 mRNA sequence and overlaps the translation initiation site (antisense oligonucleotide) Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
Mus musculus 5737
-
additional information APE/Ref-1 is equally distributed between the nucleus and the cytoplasm, whereas at 24 hours, the CD40-induced-B cell activation relocalized APE/Ref-1 in the nucleus Mus musculus
-
-
nucleus
-
Mus musculus 5634
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
DNA Mus musculus enzyme plays an important role in oxidative signalling, transcription factor regulation, and cell cycle control fragments of DNA
-
ir
additional information Mus musculus APE/Ref-1 act as tuning molecule in activated B-cells ?
-
?
additional information Mus musculus APE/Ref-1 affect the cell cycle by inducing nucleus-cytoplasm translocation of the cyclin-dependent kinase inhibitor p21 ?
-
?
additional information Mus musculus enzyme plays a role in controlling CD40-mediated B-cell proliferation, increase in proliferation and decrease in apoptosis of primary mouse B-cells activated by CD40 cross-linking and transfected with functional APE/Ref-1 antisense oligonucleotide. ?
-
?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
B-lymphocyte cell line primary cell line, murine B-cells are isolated from spleen by a negative depletion Mus musculus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
the redox activity of APE/Ref-1 is regulated by chemical reduction and oxidation in vitro Mus musculus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
DNA enzyme plays an important role in oxidative signalling, transcription factor regulation, and cell cycle control Mus musculus fragments of DNA
-
ir
additional information APE/Ref-1 act as tuning molecule in activated B-cells Mus musculus ?
-
?
additional information APE/Ref-1 affect the cell cycle by inducing nucleus-cytoplasm translocation of the cyclin-dependent kinase inhibitor p21 Mus musculus ?
-
?
additional information enzyme plays a role in controlling CD40-mediated B-cell proliferation, increase in proliferation and decrease in apoptosis of primary mouse B-cells activated by CD40 cross-linking and transfected with functional APE/Ref-1 antisense oligonucleotide. Mus musculus ?
-
?

Subunits

Subunits Comment Organism
More enzyme has a DNA repair domain at the C-terminus and a redox regulation domain at the N-terminus Mus musculus

Synonyms

Synonyms Comment Organism
APE/Ref-1
-
Mus musculus
apurinic/apyrimidinic endonuclease-1/Redox factor-1 multifunctional DNA base excision repair and redox regulation enzyme Mus musculus