Application | Comment | Organism |
---|---|---|
medicine | leading therapeutic target molecule for the oxidative stress condition or pathologic conditions such as cancer. Increased levels of APE1/Ref-1 in tumors have been associated greater resistance to chemotherapy and carry a poorer prognosis | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
nucleus | - |
Homo sapiens | 5634 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | APE1/Ref-1 also has a complex relationship to high-mobility group box 1, a protein secreted by immune cells in response to inflammatory stimuli. APE1/Ref-1 can both promote and suppress inflammatory signaling induced by high-mobility group box 1 | ? | - |
? | |
additional information | Homo sapiens | APE1/Ref-1 plays a complex role in the activation of nuclear factor kappa B, a key transcription factor involved in inflammatory and immune signaling | ? | - |
? | |
additional information | Homo sapiens | APE1/Ref-1 plays a role in cardiovascular physiology and pathophysiology. APE1/Ref-1 suppresses myocardial ischemia-reperfusion injury and vascular inflammation, and promotes endothelium-dependent vascular relaxation | ? | - |
? | |
additional information | Homo sapiens | enzyme has the ability to reductively activate redoxsensitive transcription factors and negative gene regulation by extracellular calcium | ? | - |
? | |
additional information | Homo sapiens | multifunctional protein involved in base excision DNA repair and in transcriptional regulation of gene expression, importance to genomic stability and cell survival | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
acetylation | necessary for the repression of parathyroid hormone secretion by APE1/Ref-1 | Homo sapiens |
phosphoprotein | phosphorylation of APE1/Ref-1 by several different kinases has been shown to affect both its DNA repair and reducing properties | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | APE1/Ref-1 also has a complex relationship to high-mobility group box 1, a protein secreted by immune cells in response to inflammatory stimuli. APE1/Ref-1 can both promote and suppress inflammatory signaling induced by high-mobility group box 1 | Homo sapiens | ? | - |
? | |
additional information | APE1/Ref-1 plays a complex role in the activation of nuclear factor kappa B, a key transcription factor involved in inflammatory and immune signaling | Homo sapiens | ? | - |
? | |
additional information | APE1/Ref-1 plays a role in cardiovascular physiology and pathophysiology. APE1/Ref-1 suppresses myocardial ischemia-reperfusion injury and vascular inflammation, and promotes endothelium-dependent vascular relaxation | Homo sapiens | ? | - |
? | |
additional information | enzyme has the ability to reductively activate redoxsensitive transcription factors and negative gene regulation by extracellular calcium | Homo sapiens | ? | - |
? | |
additional information | multifunctional protein involved in base excision DNA repair and in transcriptional regulation of gene expression, importance to genomic stability and cell survival | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
APE1/Ref-1 | - |
Homo sapiens |
apurinic/apyrimidinic endonuclease1/redox factor-1 | - |
Homo sapiens |