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Literature summary for 4.2.99.18 extracted from

  • Jeon, B.H.; Irani, K.
    APE1/Ref-1: Versatility in Progress (2008), Antioxid. Redox Signal., 11, 571-573.
    View publication on PubMed

Application

Application Comment Organism
medicine leading therapeutic target molecule for the oxidative stress condition or pathologic conditions such as cancer. Increased levels of APE1/Ref-1 in tumors have been associated greater resistance to chemotherapy and carry a poorer prognosis Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus
-
Homo sapiens 5634
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens APE1/Ref-1 also has a complex relationship to high-mobility group box 1, a protein secreted by immune cells in response to inflammatory stimuli. APE1/Ref-1 can both promote and suppress inflammatory signaling induced by high-mobility group box 1 ?
-
?
additional information Homo sapiens APE1/Ref-1 plays a complex role in the activation of nuclear factor kappa B, a key transcription factor involved in inflammatory and immune signaling ?
-
?
additional information Homo sapiens APE1/Ref-1 plays a role in cardiovascular physiology and pathophysiology. APE1/Ref-1 suppresses myocardial ischemia-reperfusion injury and vascular inflammation, and promotes endothelium-dependent vascular relaxation ?
-
?
additional information Homo sapiens enzyme has the ability to reductively activate redoxsensitive transcription factors and negative gene regulation by extracellular calcium ?
-
?
additional information Homo sapiens multifunctional protein involved in base excision DNA repair and in transcriptional regulation of gene expression, importance to genomic stability and cell survival ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
acetylation necessary for the repression of parathyroid hormone secretion by APE1/Ref-1 Homo sapiens
phosphoprotein phosphorylation of APE1/Ref-1 by several different kinases has been shown to affect both its DNA repair and reducing properties Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information APE1/Ref-1 also has a complex relationship to high-mobility group box 1, a protein secreted by immune cells in response to inflammatory stimuli. APE1/Ref-1 can both promote and suppress inflammatory signaling induced by high-mobility group box 1 Homo sapiens ?
-
?
additional information APE1/Ref-1 plays a complex role in the activation of nuclear factor kappa B, a key transcription factor involved in inflammatory and immune signaling Homo sapiens ?
-
?
additional information APE1/Ref-1 plays a role in cardiovascular physiology and pathophysiology. APE1/Ref-1 suppresses myocardial ischemia-reperfusion injury and vascular inflammation, and promotes endothelium-dependent vascular relaxation Homo sapiens ?
-
?
additional information enzyme has the ability to reductively activate redoxsensitive transcription factors and negative gene regulation by extracellular calcium Homo sapiens ?
-
?
additional information multifunctional protein involved in base excision DNA repair and in transcriptional regulation of gene expression, importance to genomic stability and cell survival Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
APE1/Ref-1
-
Homo sapiens
apurinic/apyrimidinic endonuclease1/redox factor-1
-
Homo sapiens