Application | Comment | Organism |
---|---|---|
medicine | APE-1 exonuclease activity plays an important role in the removal of L-configuration nucleoside analogs from DNA inside the cell and can be a determining factor in the drug resistance of the analogs | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
RKO cell lines are established, that can be induced by doxycycline to overexpress APE-1 wild-type, mutant C65A, mutant E96A or mutant E96Q | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
C65A | redox deficient mutant | Homo sapiens |
E96A | exonuclease deficient mutant | Homo sapiens |
E96Q | exonuclease deficient mutant | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytoplasm | - |
Homo sapiens | 5737 | - |
mitochondrion | - |
Homo sapiens | 5739 | - |
nucleus | - |
Homo sapiens | 5634 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Purification (Comment) | Organism |
---|---|
RKO cell protein is extracted | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
RKO cell | - |
Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
APE-1 | - |
Homo sapiens |
apurinic/apyrimidinic endonuclease-1 | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
AP endonuclease activity assay | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.5 | - |
AP endonuclease activity assay | Homo sapiens |