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Literature summary for 4.2.99.18 extracted from

  • Yoshida, A.; Ueda, T.
    Human AP endonuclease possesses a significant activity as major 3'-5' exonuclease in human leukemia cells (2003), Biochem. Biophys. Res. Commun., 310, 522-528.
    View publication on PubMed

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm translocation of the cytoplasmic enzyme into the nucleus occurs during DNA damage Homo sapiens 5737
-
nucleus
-
Homo sapiens 5634
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
37000
-
SDS-PAGE, gel filtration Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
DNA Homo sapiens
-
fragments of DNA
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
U-937 cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
DNA
-
Homo sapiens fragments of DNA
-
?
DNA cleaves the DNA phosphodiester backbone immediately 5' to an AP site, also shows 3'-phosphodiesterase activity, 3'-phosphatase activity, RNaseH and significant 3'-5'-exonuclease activity Homo sapiens fragments of DNA
-
?