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Literature summary for 4.2.99.18 extracted from

  • Xu, Y.j.; Kim, E.Y.; Demple, B.
    Excision of C-4'-oxidized deoxyribose lesions from double-stranded DNA by human apurinic/apyrimidinic endonuclease (Ape1 protein) and DNA polymerase b (1998), J. Biol. Chem., 273, 28837-28844.
    View publication on PubMed
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
DNA Homo sapiens
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 fragments of DNA
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 ?
additional information Homo sapiens enzyme stimulates polymerase beta activity on the 5'-terminal oxidized abasic residue ?
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 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
DNA
-
 Homo sapiens fragments of DNA
-
 ?
DNA catalyzes incision at the C4-keto-C-1-aldehyde site, hydrolyzes 3'-phosphoglycolates 25fold more slowly than C-4-keto-C-1-aldehydes Homo sapiens fragments of DNA
-
 ?
additional information enzyme stimulates polymerase beta activity on the 5'-terminal oxidized abasic residue Homo sapiens ?
-
 ?