Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 4.2.99.18 extracted from

  • Hahn, K.; Faustoferri, R.C.; Quivey, R.G., Jr.
    Induction of an AP endonuclease activity in Streptococcus mutans during growth at low pH (1999), Mol. Microbiol., 31, 1489-1498.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
Ca2+ 50% activity at 40 mM Streptococcus mutans
EDTA 90% inhibition at 0.1 mM Streptococcus mutans

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ optimal concentration at 5-30 mM, only 50% activity at 40 mM Streptococcus mutans
Mg2+ stimulates Streptococcus mutans
Mg2+ optimal concentration: 2.5-30 mM Streptococcus mutans

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
DNA Streptococcus mutans
-
fragments of DNA
-
?
DNA Streptococcus mutans UA159
-
fragments of DNA
-
?

Organism

Organism UniProt Comment Textmining
Streptococcus mutans
-
and strain UR100, activity is present at greater levels in cells grown at low pH than grown at pH 7
-
Streptococcus mutans UA159
-
and strain UR100, activity is present at greater levels in cells grown at low pH than grown at pH 7
-

Purification (Commentary)

Purification (Comment) Organism
500fold Streptococcus mutans

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
specific activity in the picomolar range Streptococcus mutans

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
DNA
-
Streptococcus mutans fragments of DNA
-
?
DNA enzyme has a 3' to 5' exonuclease activity and shows additional functional similarities to DNA repair enzymes Streptococcus mutans fragments of DNA
-
?
DNA specific for apurinic sites Streptococcus mutans fragments of DNA
-
?
DNA
-
Streptococcus mutans UA159 fragments of DNA
-
?
DNA enzyme has a 3' to 5' exonuclease activity and shows additional functional similarities to DNA repair enzymes Streptococcus mutans UA159 fragments of DNA
-
?
DNA specific for apurinic sites Streptococcus mutans UA159 fragments of DNA
-
?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8
-
-
Streptococcus mutans