Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 4.2.3.1 extracted from

  • Kingsbury, J.M.; McCusker, J.H.
    Threonine biosynthetic genes are essential in Cryptococcus neoformans (2008), Microbiology, 154, 2767-2775.
    View publication on PubMedView publication on EuropePMC

Application

Application Comment Organism
medicine the necessity of homoserine and/or threonine biosynthetic genes encoding aspartate kinase (HOM3), homoserine kinase (THR1) and threonine synthase (THR4) for Cryptococcus neoformans growth, particularly at physiologically relevant temperatures, makes threonine biosynthetic genes ideal anti-cryptococcal drug targets Cryptococcus neoformans

Protein Variants

Protein Variants Comment Organism
additional information Cryptococcus neoformans homoserine and/or threonine biosynthetic genes encoding aspartate kinase (HOM3), homoserine kinase (THR1) and threonine synthase (THR4) are attempted to disrupt. However, each gene proves recalcitrant to disruption, indicating that these genes are essential for Cryptococcus neoformans growth Cryptococcus neoformans

Organism

Organism UniProt Comment Textmining
Cryptococcus neoformans
-
-
-

Synonyms

Synonyms Comment Organism
THR4
-
Cryptococcus neoformans
threonine synthase
-
Cryptococcus neoformans