Literature summary for 4.2.1.75 extracted from

Hanaoka, R.; Dawid, I.B.; Kawahara, A.
Cloning and expression of zebrafish genes encoding the heme synthesis enzymes uroporphyrinogen III synthase (UROS) and protoporphyrinogen oxidase (PPO) (2007), DNA Seq., 18, 54-60.

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Cloned(Commentary)

Cloned (Comment)	Organism
-	Danio rerio

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
additional information	Danio rerio	uroporphyrinogen III synthase functions as heme synthesis enzyme during hematopoietic development of Danio rerio	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Danio rerio	Q1ET39	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
intermediate cell mass	uroporphyrinogen III synthase forms pairs of bilateral stripes in the lateral mesoderm at the 15-somite stage. At 24 h post-fertilization, uroporphyrinogen III synthase is predominantly expressed in the intermediate cell mass (ICM) that is the major site of hematopoiesis. The expression is drastically suppressed in the bloodless mutants cloche and vlad tepes/gata 1 from 15-somite to 24hpf stages, indicating that both cloche abd vlad tepes/gata 1 are required for the induction and maitenance of uroporphyrinogen III synthase expression in intermediate cell mass	Danio rerio	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	uroporphyrinogen III synthase functions as heme synthesis enzyme during hematopoietic development of Danio rerio	Danio rerio	?	-	?

Synonyms

Synonyms	Comment	Organism
Uroporphyrinogen III synthase	-	Danio rerio
UROS	-	Danio rerio

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Release 2023.1 (January 2023)