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Literature summary for 4.2.1.3 extracted from

  • Bullock, G.C.; Delehanty, L.L.; Talbot, A.L.; Gonias, S.L.; Tong, W.H.; Rouault, T.A.; Dewar, B.; Macdonald, J.M.; Chruma, J.J.; Goldfarb, A.N.
    Iron control of erythroid development by a novel aconitase-associated regulatory pathway (2010), Blood, 116, 97-108.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 4.2.1.3

Inhibitors

Inhibitors Comment Organism Structure
Fluorocitrate active site aconitase inhibitor blocks erythroid differentiation in a manner similar to iron deprivation; active site aconitase inhibitor blocks erythroid differentiation in a manner similar to iron deprivation Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Homo sapiens 5829
-
mitochondrion
-
 Homo sapiens 5739
-

Metals/Ions

Metals/Ions Comment Organism Structure
Fe iron restriction reproducibly causes 60% decreases in both mitochondrial and cytosolic aconitase activities in erythroid samples Homo sapiens
Fe2+ iron restriction reproducibly causes 60% decreases in both mitochondrial and cytosolic aconitase activities in erythroid samples Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P21399
-
-
Homo sapiens Q99798
-
-

Source Tissue

Source Tissue Comment Organism Textmining
PBMC cell purified human CD34+ progenitors derived from granulocyte-colony stimulating factor mobilized peripheral blood cells of normal donors Homo sapiens
-

Synonyms

Synonyms Comment Organism
Aco1 cytosolic aconitase Homo sapiens
Aco2 mitochondrial aconitase Homo sapiens
aconitase
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function iron restriction suppresses mitochondrial and cytosolic aconitase activity in erythroid but not granulocytic or megakaryocytic progenitors. The mechanism for aconitase regulation of erythropoiesis most likely involves both production of metabolic intermediates as well as modulation of erythropoietin signaling Homo sapiens