Cloned (Comment) | Organism |
---|---|
expression in Escherichia coli | Sus scrofa |
Crystallization (Comment) | Organism |
---|---|
computational modeling of aconitase inactivation by superoxide and nitric oxide | Sus scrofa |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
nitric oxide | brief exposure leads to a reversible inhibition competitive with isocitrate. subsequently, an irreversible inactivation is observed | Sus scrofa | |
nitrosoglutathione | irreversible inactivation both in presence and absence of substrate | Sus scrofa | |
peroxynitrite | reacts with [4Fe-4S] cluster yielding an inactive [3Fe-4S] enzyme. Carbon dioxide enhances the reaction. Peroxynitrite also induces aconitase tyrosine nitration, without contributing to inactivation | Sus scrofa |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrion | - |
Sus scrofa | 5739 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Iron | [4Fe-4S] cluster | Sus scrofa |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Sus scrofa | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
heart | - |
Sus scrofa | - |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.035 | - |
nitric oxide | reversible inhibition after brief exposure | Sus scrofa |