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Literature summary for 4.2.1.3 extracted from

  • Costello, L.C.; Liu, Y.; Franklin, R.B.; Kennedy, M.C.
    Zinc inhibition of mitochondrial aconitase and its importance in citrate metabolism of prostate epithelial cells (1997), J. Biol. Chem., 272, 28875-28881.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
Zn2+ inhibition of mitochondrial isoenzyme Bos taurus
Zn2+ competitive, the inhibitory effect is specific for the citrate to cis-aconitate reaction; inhibition of mitochondrial isoenzyme; no inhibition of the cytopsolic isoenzyme Rattus norvegicus
Zn2+ inhibition of mitochondrial isoenzyme Sus scrofa

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
Rattus norvegicus 5829
-
cytosol
-
Bos taurus 5829
-
mitochondrion
-
Rattus norvegicus 5739
-
mitochondrion
-
Sus scrofa 5739
-
mitochondrion
-
Bos taurus 5739
-

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-
Rattus norvegicus
-
-
-
Sus scrofa
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
prostate gland
-
Sus scrofa
-
prostate gland epithelium Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
citrate
-
Rattus norvegicus cis-aconitate + H2O
-
?
citrate
-
Sus scrofa cis-aconitate + H2O
-
?
citrate
-
Bos taurus cis-aconitate + H2O
-
?