Cloned (Comment) | Organism |
---|---|
- |
Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
F12L | naturally occurring variant | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.02 | - |
5-aminolevulinic acid | wild type, pH 9, octamer | Homo sapiens | |
0.2 | - |
5-aminolevulinic acid | wild type, pH 7, almost octamer | Homo sapiens | |
4.5 | - |
5-aminolevulinic acid | wild type, pH 9, predominantly hexamer and/or dimer | Homo sapiens | |
4.6 | - |
5-aminolevulinic acid | F12L, pH 9 | Homo sapiens | |
18 | - |
5-aminolevulinic acid | F12L, pH 7 | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P13716 | - |
- |
Purification (Comment) | Organism |
---|---|
- |
Homo sapiens |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
0.67 | - |
wild-type octamer | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
5-aminolevulinic acid + 5-aminolevulinic acid | - |
Homo sapiens | porphobilinogen + 2 H2O | - |
? |
Subunits | Comment | Organism |
---|---|---|
dimer | pro-hexamer dimer and pro-octamer dimer, analyzed by gel filtration | Homo sapiens |
hexamer | wild type, pH 8.8, catalytic turnover favors octamer, analyzed by gel filtration and anion exchange chromatography | Homo sapiens |
octamer | wild type, pH 6.9 and pH 8.8, analyzed by gel filtration and anion exchange chromatography | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
Porphobilinogen synthase | - |
Homo sapiens |