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Literature summary for 4.2.1.20 extracted from

  • Wolf, D.H.; Hoffmann, M.
    Tryptophan synthase from yeast. Purification by affinity chromatography, physical properties (1974), Eur. J. Biochem., 45, 269-276.
    View publication on PubMed

General Stability

General Stability Organism
influence of ionic strength, stable in 1 M phosphate buffer, instable in 0.1M or 0.01 M phosphate buffer Saccharomyces cerevisiae

Inhibitors

Inhibitors Comment Organism Structure
5,5'-dithiobis(2-nitrobenzoate)
-
Saccharomyces cerevisiae
GSH
-
Saccharomyces cerevisiae
indoleacetic acid 3.5 mM, 50% inhibition Saccharomyces cerevisiae
indoleacrylic acid 0.05 mM, 50% inhibition Saccharomyces cerevisiae
indolebutyric acid 7.5 mM, 50% inhibition Saccharomyces cerevisiae
Indolepropionic acid 7.5 mM, 50% inhibition Saccharomyces cerevisiae
indolepyruvic acid 2.3 mM, 50% inhibition Saccharomyces cerevisiae
L-cysteine
-
Saccharomyces cerevisiae
PCMB
-
Saccharomyces cerevisiae

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.07
-
1-(indol-3-yl)glycerol 3-phosphate cosubstrate L-Ser Saccharomyces cerevisiae
0.16
-
indole cosubstrate L-Ser Saccharomyces cerevisiae
0.5
-
1-(indol-3-yl)glycerol 3-phosphate no cosubstrate Saccharomyces cerevisiae
5.3
-
L-Ser cosubstrate indole Saccharomyces cerevisiae

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Saccharomyces cerevisiae

Storage Stability

Storage Stability Organism
4°C, 1 M potassium phosphate buffer, pH 7.6, 1 mM pyridoxal 5'-phosphate, 2 mM PMSF, 24 h, 7% loss of activity Saccharomyces cerevisiae

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1-(indol-3-yl)glycerol 3-phosphate + L-serine
-
Saccharomyces cerevisiae L-tryptophan + D-glyceraldehyde 3-phosphate + H2O
-
?
indole + L-serine
-
Saccharomyces cerevisiae L-tryptophan + H2O
-
?
indole-3-glycerol phosphate
-
Saccharomyces cerevisiae indole + D-glyceraldehyde 3-phosphate
-
?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6.9 7
-
Saccharomyces cerevisiae

pH Stability

pH Stability pH Stability Maximum Comment Organism
6 7.5
-
Saccharomyces cerevisiae

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.05
-
indoleacrylic acid
-
Saccharomyces cerevisiae
2.3
-
indolepyruvic acid
-
Saccharomyces cerevisiae
3.5
-
indoleacetic acid
-
Saccharomyces cerevisiae
7.5
-
Indolepropionic acid
-
Saccharomyces cerevisiae
7.5
-
indolebutyric acid
-
Saccharomyces cerevisiae