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Literature summary for 4.2.1.2 extracted from

  • Raimundo, N.; Ahtinen, J.; Fumic, K.; Baric, I.; Remes, A.M.; Renkonen, R.; Lapatto, R.; Suomalainen, A.
    Differential metabolic consequences of fumarate hydratase and respiratory chain defects (2008), Biochim. Biophys. Acta, 1782, 287-294.
    View publication on PubMed
Search for more literature for 4.2.1.2

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
 Homo sapiens 5737
-
mitochondrion
-
 Homo sapiens 5739
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
48000
-
 mitochondrial fumarate hydratase is translated as an approximately 54000 Da precursor, which is processed upon mitochondrial transport by cleavage of the N-terminal targeting signal, resulting in a mature form of 48000 Da Homo sapiens
54000
-
 mitochondrial fumarate hydratase is translated as an approximately 54000 Da precursor, which is processed upon mitochondrial transport by cleavage of the N-terminal targeting signal, resulting in a mature form of 48000 Da Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens fumarate hydratase is a key enzyme of the tricarboxylic cycle ?
-
 ?
additional information Homo sapiens hypoxia activation due to fumarate accumulation may be a tissue-specific response ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
fibroblast
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information fumarate hydratase is a key enzyme of the tricarboxylic cycle Homo sapiens ?
-
 ?
additional information hypoxia activation due to fumarate accumulation may be a tissue-specific response Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
fumarase
-
 Homo sapiens