Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 4.2.1.17 extracted from

  • Mohrig, J.R.; Reiter, N.J.; Kirk, R.; Zawadski, M.R.; Lamarre-Vincent, N.
    Effect of buffer general acid-base catalysis on the stereoselectivity of ester and thioester H/D exchange in D2O (2011), J. Am. Chem. Soc., 133, 5124-5128.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens catalysis by enoyl-CoA hydratase involves two glutamic acid residues at the active site, which are part of a hydrogen bonding network with the molecule of water that is added to the CdC.17 The C-2 deuteron is transferred by a glutamic acid residue acting as a Bronsted general acid. Buffer effect on the stereoselectivity of protonation of an enolate anion with a Bronsted acid that, overview ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Reaction

Reaction Comment Organism Reaction ID
(3S)-3-hydroxyacyl-CoA = trans-2(or 3)-enoyl-CoA + H2O reaction mechanism, overview Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information catalysis by enoyl-CoA hydratase involves two glutamic acid residues at the active site, which are part of a hydrogen bonding network with the molecule of water that is added to the CdC.17 The C-2 deuteron is transferred by a glutamic acid residue acting as a Bronsted general acid. Buffer effect on the stereoselectivity of protonation of an enolate anion with a Bronsted acid that, overview Homo sapiens ?
-
?