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Literature summary for 4.2.1.10 extracted from
- Structure-based inhibitor discovery of Helicobacter pylori dehydroquinate synthase (2008), Biochem. Biophys. Res. Commun., 373, 1-7.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | dehydroquinate synthase is a target for microbial agents, anti-parasitic agents and herbicides | Helicobacter pylori |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| into the pQE30 vector for expression in Escherichia coli JM109 cells | Helicobacter pylori |
Crystallization (Commentary)
| Crystallization (Comment) | Organism |
|---|---|
| the crystal structure of dehydroquinate synthase complexed with NAD is determined at 2.4 A resolution | Helicobacter pylori |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| carbaphosphonate | - |
Helicobacter pylori |  |
| HTS 11955 | - |
Helicobacter pylori | |
| RH00573 | - |
Helicobacter pylori | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 3-deoxy-D-arabino-heptulosonate 7-phosphate | Helicobacter pylori | - |
3-dehydroquinate + phosphate | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Helicobacter pylori | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| purified by immobilized nickel-ion chromatography | Helicobacter pylori |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 3-deoxy-D-arabino-heptulosonate 7-phosphate | - |
Helicobacter pylori | 3-dehydroquinate + phosphate | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| dehydroquinate synthase | - |
Helicobacter pylori |
| DHQS | - |
Helicobacter pylori |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
enzymatic assay | Helicobacter pylori |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7 | - |
enzymatic assay | Helicobacter pylori |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NAD+ | - |
Helicobacter pylori | |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0000008 | - |
carbaphosphonate | - |
Helicobacter pylori | |
IC50 Value
| IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|
| 0.061 | - |
- |
Helicobacter pylori | HTS 11955 | |
| 0.0845 | - |
- |
Helicobacter pylori | RH00573 | |
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Release 2023.1 (January 2023)
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