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Literature summary for 4.1.3.1 extracted from

  • Lee, Y.J.; Han, Y.R.; Park, W.; Nam, S.H.; Oh, K.B.; Lee, H.S.
    Synthetic analogs of indole-containing natural products as inhibitors of sortase A and isocitrate lyase (2010), Bioorg. Med. Chem. Lett., 20, 6882-6885.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
-
Candida albicans

Inhibitors

Inhibitors Comment Organism Structure
1,2-bis(5-hydroxy-1H-indol-3-yl)ethane-1,2-dione
-
Candida albicans
1-(2-aminoethyl)-1H-indol-6-ol
-
Candida albicans
1-(3-methoxyphenyl)-2,3,4,9-tetrahydro-1H-b-carboline
-
Candida albicans
1-(4-methoxyphenyl)-2,3,4,9-tetrahydro-1H-b-carboline
-
Candida albicans
1-(naphthalen-2-yl)-2,3,4,9-tetrahydro-1H-b-carboline
-
Candida albicans
2-hydroxy-1-(5-hydroxy-1H-indol-3-yl)ethanone
-
Candida albicans
3-nitropropionate
-
Candida albicans
5-hydroxy-1H-indole-3-carbaldehyde
-
Candida albicans
6-hydroxy-4,9-dihydro-3H-beta-carboline-1-carboxylic acid
-
Candida albicans

Organism

Organism UniProt Comment Textmining
Candida albicans
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Candida albicans

Synonyms

Synonyms Comment Organism
isocitrate lyase
-
Candida albicans

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.051
-
pH not specified in the publication, temperature not specified in the publication Candida albicans 3-nitropropionate
0.075
-
pH not specified in the publication, temperature not specified in the publication Candida albicans 1-(3-methoxyphenyl)-2,3,4,9-tetrahydro-1H-b-carboline
0.089
-
pH not specified in the publication, temperature not specified in the publication Candida albicans 1,2-bis(5-hydroxy-1H-indol-3-yl)ethane-1,2-dione
0.137
-
pH not specified in the publication, temperature not specified in the publication Candida albicans 1-(naphthalen-2-yl)-2,3,4,9-tetrahydro-1H-b-carboline
0.18
-
pH not specified in the publication, temperature not specified in the publication Candida albicans 1-(4-methoxyphenyl)-2,3,4,9-tetrahydro-1H-b-carboline
0.247
-
pH not specified in the publication, temperature not specified in the publication Candida albicans 5-hydroxy-1H-indole-3-carbaldehyde
0.301
-
pH not specified in the publication, temperature not specified in the publication Candida albicans 1-(2-aminoethyl)-1H-indol-6-ol
0.318
-
pH not specified in the publication, temperature not specified in the publication Candida albicans 2-hydroxy-1-(5-hydroxy-1H-indol-3-yl)ethanone
0.38
-
pH not specified in the publication, temperature not specified in the publication Candida albicans 6-hydroxy-4,9-dihydro-3H-beta-carboline-1-carboxylic acid