Literature summary for 4.1.3.1 extracted from

Sriram, D.; Yogeeswari, P.; Senthilkumar, P.; Dewakar, S.; Rohit, N.; Debjani, B.; Bhat, P.; Veugopal, B.; Pavan, V.V.; Thimmappa, H.M.
Novel phthalazinyl derivatives: synthesis, antimycobacterial activities, and inhibition of Mycobacterium tuberculosis isocitrate lyase enzyme (2009), Med. Chem., 5, 422-433.

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Inhibitors

Inhibitors	Comment	Organism	Structure
additional information	some 2-[3-(4-bromo-2-fluorobenzyl)-4-oxo-3,4-dihydro-1-phthalazinyl]acetic acid hydrazones show 45-61% inhibition at 10 mM	Mycobacterium tuberculosis
N'1-[(4-nitrophenyl)methylene]-2-[3-(4-bromo-2-fluorobenzyl)-4-oxo-1,2,3,4-tetrahydro-1-phthalazinyl]ethanohydrazide	is the most active compound	Mycobacterium tuberculosis

Organism

Organism	UniProt	Comment	Textmining
Mycobacterium tuberculosis	-	-	-

Synonyms

Synonyms	Comment	Organism
ICL	-	Mycobacterium tuberculosis
isocitrate lyase	-	Mycobacterium tuberculosis

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Release 2023.1 (January 2023)