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Literature summary for 4.1.3.1 extracted from

  • Lee, H.S.; Lee, T.H.; Lee, J.H.; Chae, C.S.; Chung, S.C.; Shin, D.S.; Shin, J.; Oh, K.B.
    Inhibition of the pathogenicity of Magnaporthe grisea by bromophenols, isocitrate lyase inhibitors, from the red alga Odonthalia corymbifera (2007), J. Agric. Food Chem., 55, 6923-6928.
    View publication on PubMed
Search for more literature for 4.1.3.1

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli strain BLR (DE3) Pyricularia grisea

Inhibitors

Inhibitors Comment Organism Structure
2,2',3,3'-tetrabromo-4,4',5,5'-tetrahydroxydiphenylmethane
-
 Pyricularia grisea
2,2',3-tribromo-3',4,4',5-tetrahydroxy-6'-hydroxymethyldiphenylmethane
-
 Pyricularia grisea
2,3-dibromo-4,5-dihydroxybenzyl alcohol
-
 Pyricularia grisea
2,3-dibromo-4,5-dihydroxybenzyl methyl ether
-
 Pyricularia grisea
3,5-dibromo-4-hydroxyphenylethylamine
-
 Pyricularia grisea
3-bromo-4-(2,3-dibromo-4,5-dihydroxybenzyl)-5-methoxymethylpyrocatechol
-
 Pyricularia grisea
3-nitropropionate
-
 Pyricularia grisea
additional information not inhibited by bromopyruvate Pyricularia grisea

Organism

Organism UniProt Comment Textmining
Pyricularia grisea
-
-
-
Pyricularia grisea Guy 11
-
-
-

Purification (Commentary)

Purification (Comment) Organism
Ni-NTA column chromatography Pyricularia grisea

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
isocitrate
-
 Pyricularia grisea succinate + glyoxylate
-
 ?
isocitrate
-
 Pyricularia grisea Guy 11 succinate + glyoxylate
-
 ?

Synonyms

Synonyms Comment Organism
ICL key enzyme in the glyoxylate cycle Pyricularia grisea

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.002
-
 in 20 mM sodium phosphate buffer (pH 7.0), with 3.75 mM MgCl2 and 4.1 mM phenylhydrazine, at 37°C Pyricularia grisea 2,2',3,3'-tetrabromo-4,4',5,5'-tetrahydroxydiphenylmethane
0.0021
-
 in 20 mM sodium phosphate buffer (pH 7.0), with 3.75 mM MgCl2 and 4.1 mM phenylhydrazine, at 37°C Pyricularia grisea 3-bromo-4-(2,3-dibromo-4,5-dihydroxybenzyl)-5-methoxymethylpyrocatechol
0.0028
-
 in 20 mM sodium phosphate buffer (pH 7.0), with 3.75 mM MgCl2 and 4.1 mM phenylhydrazine, at 37°C Pyricularia grisea 2,2',3-tribromo-3',4,4',5-tetrahydroxy-6'-hydroxymethyldiphenylmethane
0.0924
-
 in 20 mM sodium phosphate buffer (pH 7.0), with 3.75 mM MgCl2 and 4.1 mM phenylhydrazine, at 37°C Pyricularia grisea 3-nitropropionate
0.0926
-
 in 20 mM sodium phosphate buffer (pH 7.0), with 3.75 mM MgCl2 and 4.1 mM phenylhydrazine, at 37°C Pyricularia grisea 2,3-dibromo-4,5-dihydroxybenzyl alcohol
0.116
-
 in 20 mM sodium phosphate buffer (pH 7.0), with 3.75 mM MgCl2 and 4.1 mM phenylhydrazine, at 37°C Pyricularia grisea 3,5-dibromo-4-hydroxyphenylethylamine
0.1256
-
 in 20 mM sodium phosphate buffer (pH 7.0), with 3.75 mM MgCl2 and 4.1 mM phenylhydrazine, at 37°C Pyricularia grisea 2,3-dibromo-4,5-dihydroxybenzyl methyl ether